8H78

Crystal structure of human MMP-2 catalytic domain in complex with inhibitor

Summary for 8H78

• Entry DOI: 10.2210/pdb8h78/pdb
• Descriptor: Matrix metalloproteinase-2, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: gelatinase a, matrix metalloproteinase-2, 72 kda type iv collagenase, hydrolase
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 40050.90

Authors

Kamitani, M.,Takeuchi, T.,Mima, M. (deposition date: 2022-10-19, release date: 2023-01-18, Last modification date: 2023-11-29)

• Primary citation: Takeuchi, T.,Nomura, Y.,Tamita, T.,Nishikawa, R.,Kakinuma, H.,Kojima, N.,Hitaka, K.,Tamura, Y.,Kamitani, M.,Mima, M.,Nozoe, A.,Hayashi, M.; Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.; J.Med.Chem., 66:822-836, 2023; PubMed: 36595440; DOI: 10.1021/acs.jmedchem.2c01698

Experimental method

X-RAY DIFFRACTION (2.4 Å)