7QKH
 
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7QJX
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7QKJ
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8OTH
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8OT6
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8OTJ
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8OT9
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8OTI
 | | CTE typeIII tau filament | | 分子名称: | Microtubule-associated protein tau | | 著者 | Tetter, S, Qi, C, Ryskeldi-Falcon, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-04-20 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8OTC
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8OTG
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8PPO
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8Q92
 | | P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line | | 分子名称: | Microtubule-associated protein tau | | 著者 | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-08-19 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Acta Neuropathol Commun, 11, 2023
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8Q96
 | | P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line | | 分子名称: | Isoform Tau-E of Microtubule-associated protein tau, Unknown protein | | 著者 | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | | 登録日 | 2023-08-19 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Acta Neuropathol Commun, 11, 2023
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8R3T
 | | Cofactor-free Tau 4R2N isoform | | 分子名称: | Microtubule-associated protein tau | | 著者 | Limorenko, G, Tatli, M, Kolla, R, Nazarov, S, Weil, M.T, Schondorf, D.C, Geist, D, Reinhardt, P, Ehrnhoefer, D.E, Stahlberg, H, Gasparini, L, Lashuel, H.A. | | 登録日 | 2023-11-10 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.
Nat Commun, 14, 2023
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8SEH
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8SEI
 | | SF Tau from Down Syndrome | | 分子名称: | Microtubule-associated protein tau | | 著者 | Hoq, M.R, Bharath, S.R, Jiang, W, Vago, F.S, Bharath, S.R. | | 登録日 | 2023-04-10 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 2024
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5HF3
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma | | 分子名称: | 14-3-3 protein sigma, modified Tau peptide | | 著者 | Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. | | 登録日 | 2016-01-06 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4Y3B
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma | | 分子名称: | (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C | | 著者 | Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. | | 登録日 | 2015-02-10 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4Y32
 | | Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma | | 分子名称: | (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC | | 著者 | Bartel, M, Milroy, L, Bier, D, Brunsveld, L, Ottmann, C. | | 登録日 | 2015-02-10 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 54, 2015
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5BTV
 | | Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ottmann, C, Schumacher, B, Bartel, M. | | 登録日 | 2015-06-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2019-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Faseb J., 29, 2015
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5DMG
 | | X-RAY STRUCTURE OF THE FAB FRAGMENT OF THE ANTI TAU ANTIBODY RB86 IN COMPLEX WITH THE PHOSPHORYLATED TAU PEPTIDE (416-430) | | 分子名称: | Microtubule-associated protein, RB86 antibody Fab fragment heavy chain, RB86 antibody Fab fragment light chain | | 著者 | Benz, J, Lorenz, S, Georges, G, Jochner, A, Goepfert, U, Grueninger, F, Bujotzek, A. | | 登録日 | 2015-09-08 | | 公開日 | 2015-12-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | VH-VL orientation prediction for antibody humanization candidate selection: A case study.
Mabs, 8, 2016
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5MP3
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8FYU
 | | Crystal structure of the human CHIP-TPR domain in complex with a 10mer acetylated tau peptide | | 分子名称: | ACE-SER-SER-THR-GLY-SER-ILE-ASP-MET-VAL-ASP, E3 ubiquitin-protein ligase CHIP | | 著者 | Wucherer, K, Bohn, M.F, Basu, K, Nadel, C.M, Gestwicki, J.E, Craik, C.S. | | 登録日 | 2023-01-26 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.84839141 Å) | | 主引用文献 | Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
Biorxiv, 2023
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6CVN
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6CVJ
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