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PDB: 92 件
7KH8
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Human LMPTP in complex with inhibitor
分子名称: 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION
著者Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B.
登録日2020-10-20
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
J.Med.Chem., 64, 2021
7UW6
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BU of 7uw6 by Molmil
The co-crystal structure of low molecular weight protein tyrosine phosphatase (LMW-PTP) with a small molecule inhibitor SPAA-2
分子名称: 2-[(1,3-benzothiazol-2-yl)amino]-2-oxoethane-1-sulfonic acid, Low molecular weight phosphotyrosine protein phosphatase
著者Wang, J, Zhang, Z.Y.
登録日2022-05-02
公開日2022-10-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
J.Med.Chem., 65, 2022
4PIC
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BU of 4pic by Molmil
YwlE arginine phosphatase from Geobacillus stearothermophilus
分子名称: Arginine phosphatase Ywle, PHOSPHATE ION, SULFATE ION
著者Clausen, T, Fuhrmann, J.
登録日2014-05-08
公開日2014-05-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Chasing phosphoarginine proteins: development of a selective enrichment method using a phosphatase trap.
Mol.Cell Proteomics, 2014
5Z3M
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BU of 5z3m by Molmil
Crystal structure of Low Molecular Weight Phosphotyrosine phosphatase (VcLMWPTP-2) from Vibrio choleraeO395
分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Phosphotyrosine protein phosphatase, ...
著者Chatterjee, S, Nath, S, Sen, U.
登録日2018-01-08
公開日2018-09-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Vibrio cholerae LMWPTP-2 display unique surface charge and grooves around the active site: Indicative of distinctive substrate specificity and scope to design specific inhibitor.
Biochim Biophys Acta Proteins Proteom, 1867, 2019
7BTG
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BU of 7btg by Molmil
Crystal structure of DARP, drosophila arginine phosphatase
分子名称: CHLORIDE ION, GEO10716p1, PHOSPHATE ION
著者Lee, H.S, Mo, Y, Ku, B, Kim, S.J.
登録日2020-04-01
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.188 Å)
主引用文献Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1.
Mol.Cells, 43, 2020
8P5N
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Arsenate reductase (ArsC2) from Deinococcus indicus, co-crystallized with arsenate
分子名称: ARSENATE, GLYCEROL, Low molecular weight phosphatase family protein
著者Gouveia, A.G, Matias, P.M, Romao, C.V.
登録日2023-05-24
公開日2023-08-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus .
Front Microbiol, 14, 2023
8P6M
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Arsenate reductase (ArsC2) from Deinococcus indicus
分子名称: Low molecular weight phosphatase family protein
著者Gouveia, A.G, Matias, P.M, Romao, C.V.
登録日2023-05-26
公開日2023-08-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Unraveling the multifaceted resilience of arsenic resistant bacterium Deinococcus indicus .
Front Microbiol, 14, 2023
5O7B
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CRYSTAL STRUCTURE OF THE SLR0328 TYROSINE PHOSPHATASE WZB FROM SYNECHOCYSTIS SP. PCC 6803
分子名称: Putative low molecular weight protein-tyrosine-phosphatase slr0328
著者Leite, J.P, Gales, L.
登録日2017-06-08
公開日2018-06-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.281 Å)
主引用文献The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803.
Microbiologyopen, 2019
6Y2V
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BU of 6y2v by Molmil
Crystal structure of the double mutant L13R I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP)
分子名称: Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION, TRIETHYLENE GLYCOL
著者Levy, C.
登録日2020-02-17
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Plos One, 15, 2020
6Y2W
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BU of 6y2w by Molmil
Crystal structure of the single mutant I16K of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP)
分子名称: ACETATE ION, Low molecular weight phosphotyrosine protein phosphatase
著者Levy, C.
登録日2020-02-17
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Plos One, 15, 2020
5PNT
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BU of 5pnt by Molmil
CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE
著者Zhang, M, Stauffacher, C, Lin, D, Vanetten, R.
登録日1998-04-29
公開日1998-10-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity.
J.Biol.Chem., 273, 1998
2WJA
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BU of 2wja by Molmil
Crystal structure of the tyrosine phosphatase Wzb from Escherichia coli K30 in complex with phosphate.
分子名称: NICKEL (II) ION, PHOSPHATE ION, PUTATIVE ACID PHOSPHATASE WZB
著者Huang, H, Hagelueken, G, Whitfield, C, Naismith, J.H.
登録日2009-05-25
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of Wzb of Escherichia Coli and Cpsb of Streptococcus Pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly.
J.Mol.Biol., 392, 2009
2WMY
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BU of 2wmy by Molmil
Crystal structure of the tyrosine phosphatase Wzb from Escherichia coli K30 in complex with sulphate.
分子名称: NICKEL (II) ION, PUTATIVE ACID PHOSPHATASE WZB, SULFATE ION
著者Huang, H, Hagelueken, G, Whitfield, C, Naismith, J.H.
登録日2009-07-03
公開日2009-07-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.211 Å)
主引用文献Crystal Structures of the Capsular Export Regulating Tyrosine Phosphatases Wzb of Escherichia Coli and Cpsb of Streptococcus Pneumoniae.
To be Published
3ILY
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BU of 3ily by Molmil
Apo crystal structure of protein tyrosine phosphatase from Entamoeba histolytica featuring a disordered active site
分子名称: Protein tyrosine phosphatase, putative
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-08-07
公開日2009-08-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Mol.Biochem.Parasitol., 193, 2014
3IDO
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BU of 3ido by Molmil
Crystal structure of protein tyrosine phosphatase from Entamoeba histolytica with a phosphotyrosine crude mimic HEPES molecule in the active site
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-07-21
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Mol.Biochem.Parasitol., 193, 2014
3JVI
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BU of 3jvi by Molmil
Product state mimic crystal structure of protein tyrosine phosphatase from Entamoeba histolytica
分子名称: Protein tyrosine phosphatase, SULFATE ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-09-16
公開日2009-09-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Mol.Biochem.Parasitol., 193, 2014
3JS5
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BU of 3js5 by Molmil
Crystal structure of protein tyrosine phosphatase from Entamoeba histolytica with Hepes in the active site. High resolution, alternative crystal form with 1 molecule in asymmetric unit
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase, SODIUM ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-09-09
公開日2009-09-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.
Mol.Biochem.Parasitol., 193, 2014
4KK3
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BU of 4kk3 by Molmil
YwlE arginine phosphatase - wildtype
分子名称: Low molecular weight protein-tyrosine-phosphatase YwlE, PHOSPHATE ION
著者Fuhrmann, J, Clausen, T.
登録日2013-05-05
公開日2013-07-03
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria.
Cell Rep, 3, 2013
4KK4
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BU of 4kk4 by Molmil
YwlE arginine phosphatase - C7S mutant with phosphorylated active site serine
分子名称: Low molecular weight protein-tyrosine-phosphatase YwlE
著者Fuhrmann, J, Clausen, T.
登録日2013-05-05
公開日2013-07-03
最終更新日2013-07-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteria.
Cell Rep, 3, 2013
3RH0
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BU of 3rh0 by Molmil
Corynebacterium glutamicum mycothiol/mycoredoxin1-dependent arsenate reductase Cg_ArsC2
分子名称: ARSENATE REDUCTASE
著者Messens, J, Wahni, K, Dufe, T.V.
登録日2011-04-11
公開日2011-11-30
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.724 Å)
主引用文献Corynebacterium glutamicum survives arsenic stress with arsenate reductases coupled to two distinct redox mechanisms
Mol.Microbiol., 82, 2011
3ROF
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BU of 3rof by Molmil
Crystal Structure of the S. aureus Protein Tyrosine Phosphatase PtpA
分子名称: Expression tag cleaved from protein-tyrosine-phosphatase ptpA, Low molecular weight protein-tyrosine-phosphatase ptpA, PHOSPHATE ION
著者Grundner, C, Chou, S, Engel, K.
登録日2011-04-25
公開日2011-09-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.03 Å)
主引用文献Structure and substrate recognition of the Staphylococcus aureus protein tyrosine phosphatase PtpA.
J.Mol.Biol., 413, 2011
6U1P
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Crystal structure of VpsU (VC0916) from Vibrio cholerae
分子名称: GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase
著者Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M.
登録日2019-08-16
公開日2020-08-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
4Z99
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BU of 4z99 by Molmil
Crystal structure of the apo Low Molecular Weight Protein Tyrosine Phosphatase isoform A
分子名称: Low molecular weight phosphotyrosine protein phosphatase
著者Fonseca, E.M.B, Scorsato, V, Dias, M.P, de Oliveria, F.L, Miranda, P.C.M.L, Aparicio, R.
登録日2015-04-10
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Bioorg.Med.Chem., 23, 2015
4Z9B
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BU of 4z9b by Molmil
Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with benzylphosphonic acid
分子名称: Low molecular weight phosphotyrosine protein phosphatase, benzylphosphonic acid
著者Fonseca, E.M.B, Trivella, D.B.B, Scorsato, V, Dias, M.P, de Oliveira, F.L, Miranda, P.C.M.L, Aparicio, R.
登録日2015-04-10
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Bioorg.Med.Chem., 23, 2015
4Z9A
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Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with phenylmethanesulfonic acid
分子名称: GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase, SULFATE ION, ...
著者Trivella, D.B.B, Fonseca, E.M.B, Scorsato, V, Dias, M.P, Aparicio, R.
登録日2015-04-10
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.
Bioorg.Med.Chem., 23, 2015

 

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