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PDB: 10 results
6UJO
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BU of 6ujo by Molmil
HHAT L75F Neoantigen Peptide KQWLVWLFL Presented by HLA-A206
Descriptor: Beta-2-microglobulin, MHC class I antigen, Protein-cysteine N-palmitoyltransferase HHAT
Authors:Devlin, J.R, Baker, B.M, Vander Kooi, C.
Deposit date:2019-10-03
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Nat.Chem.Biol., 16, 2020
6UJQ
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BU of 6ujq by Molmil
HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206
Descriptor: Beta-2-microglobulin, MHC class I antigen, Protein-cysteine N-palmitoyltransferase HHAT
Authors:Devlin, J.R, Baker, B.M, Singh, N.K.
Deposit date:2019-10-03
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Nat.Chem.Biol., 16, 2020
7MHY
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BU of 7mhy by Molmil
Human Hedgehog acyltransferase (HHAT) in complex with palmitoyl-CoA and two Fab antibody fragments
Descriptor: 1C06 Fab heavy chain, 1C06 Fab light chain, 3H02 Fab heavy chain, ...
Authors:Long, S.B, Jiang, Y.
Deposit date:2021-04-16
Release date:2021-06-16
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT.
Science, 372, 2021
6UK4
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BU of 6uk4 by Molmil
Complex of T cell Receptor with HHAT Neoantigen Peptide KQWLVWLFL Presented by HLA-A206
Descriptor: 302 TIL T cell receptor alpha chain, 302 TIL T cell receptor beta chain, Beta-2-microglobulin, ...
Authors:Devlin, J.R, Baker, B.M.
Deposit date:2019-10-04
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Nat.Chem.Biol., 16, 2020
7Q1U
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BU of 7q1u by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map)
Descriptor: CHOLESTEROL, MAGNESIUM ION, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-10-21
Release date:2022-06-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021
7URF
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BU of 7urf by Molmil
Human HHAT H379C in complex with SHH N-terminal peptide
Descriptor: 3H02 heavy chain, 3H02 light chain, Digitonin, ...
Authors:Liu, Y, Qi, X, Li, X.
Deposit date:2022-04-21
Release date:2022-07-20
Last modified:2022-08-10
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
6P64
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BU of 6p64 by Molmil
Alpha-beta TCR Binding to Neoantigen KQWLVWLFL Presented by HLA-A206
Descriptor: 302TIL TCR alpha chain, 302TIL TCR beta chain, Beta-2-microglobulin, ...
Authors:Devlin, J.R, Baker, B.M.
Deposit date:2019-05-31
Release date:2020-06-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:A T cell receptor peptide/MHC complex at 3.05 Angstrom resolution
To be Published
6UK2
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BU of 6uk2 by Molmil
Complex of T cell Receptor with HHAT Wild Type Peptide KQWLVWLLL Presented by HLA-A206
Descriptor: 302 TIL T cell receptor alpha chain, 302 TIL T cell receptor beta chain, Beta-2-microglobulin, ...
Authors:Devlin, J.R, Baker, B.M.
Deposit date:2019-10-04
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.138808 Å)
Cite:Structural dissimilarity from self drives neoepitope escape from immune tolerance.
Nat.Chem.Biol., 16, 2020
7MHZ
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BU of 7mhz by Molmil
Human Hedgehog acyltransferase (HHAT) in complex with a palmitoylated Hedgehog peptide product and a Fab antibody fragment
Descriptor: 3H02 Fab heavy chain, 3H02 Fab light chain, Digitonin, ...
Authors:Long, S.B, Jiang, Y.
Deposit date:2021-04-16
Release date:2021-06-16
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT.
Science, 372, 2021
7Q6Z
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BU of 7q6z by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Descriptor: 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-11-09
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021

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