8RQC
| Crystal structure of CRBN-midi in complex with mezigdomide and IKZF1 ZF2 | Descriptor: | DNA-binding protein Ikaros, Mezigdomide, Protein cereblon, ... | Authors: | Furihata, H, Kroupova, A, Zollman, D, Ciulli, A. | Deposit date: | 2024-01-17 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders To Be Published
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8TNQ
| Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | Descriptor: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | Authors: | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | Deposit date: | 2023-08-02 | Release date: | 2024-03-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNR
| Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | Descriptor: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | Authors: | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | Deposit date: | 2023-08-02 | Release date: | 2024-03-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8D7Z
| Cereblon-DDB1 bound to CC-92480 and Ikaros ZF1-2-3 | Descriptor: | DNA damage-binding protein 1, DNA-binding protein Ikaros, Mezigdomide, ... | Authors: | Watson, E.R, Lander, G.C. | Deposit date: | 2022-06-07 | Release date: | 2022-07-20 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
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6H0F
| Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) | Descriptor: | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ... | Authors: | Petzold, G, Bunker, R.D, Thoma, N.H. | Deposit date: | 2018-07-09 | Release date: | 2018-11-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362, 2018
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8TNP
| Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | Descriptor: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | Authors: | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | Deposit date: | 2023-08-02 | Release date: | 2024-03-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8D80
| Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3 | Descriptor: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, DNA-binding protein Ikaros, ... | Authors: | Watson, E.R, Lander, G.C. | Deposit date: | 2022-06-07 | Release date: | 2022-07-20 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
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