5V69
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7NT4
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![BU of 7nt4 by Molmil](/molmil-images/mine/7nt4) | X-ray structure of SCoV2-PLpro in complex with small molecule inhibitor | Descriptor: | 1,2-ETHANEDIOL, Non-structural protein 3, PROFLAVIN, ... | Authors: | Napolitano, V, Mourao, A, Bostock, M, Matsuda, A, Czarna, A, Popowicz, G.M. | Deposit date: | 2021-03-09 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chem Biol, 29, 2022
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7SQE
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![BU of 7sqe by Molmil](/molmil-images/mine/7sqe) | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with Jun9-84-3 inhibitor | Descriptor: | (1R)-N-[(1H-indol-3-yl)methyl]-N-methyl-1-(naphthalen-1-yl)ethan-1-amine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Wang, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-11-05 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with Jun9-84-3 inhibitor To be Published
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5KO3
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8IHO
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![BU of 8iho by Molmil](/molmil-images/mine/8iho) | Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors | Descriptor: | Papain-like protease nsp3, ZINC ION, covalent inhibitor | Authors: | Wang, Q, Hu, H, Li, M, Xu, Y. | Deposit date: | 2023-02-23 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease. Int J Mol Sci, 24, 2023
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6W9C
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![BU of 6w9c by Molmil](/molmil-images/mine/6w9c) | The crystal structure of papain-like protease of SARS CoV-2 | Descriptor: | CHLORIDE ION, Non-structural protein 3, ZINC ION | Authors: | Osipiuk, J, Jedrzejczak, R, Tesar, C, Endres, M, Stols, L, Babnigg, G, Kim, Y, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-03-22 | Release date: | 2020-04-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of papain-like protease of SARS CoV-2 to be published
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4RNA
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![BU of 4rna by Molmil](/molmil-images/mine/4rna) | Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus | Descriptor: | PHOSPHATE ION, ZINC ION, papain-like protease | Authors: | Lei, H, Santarsiero, B.D, Lee, H, Johnson, M.E. | Deposit date: | 2014-10-23 | Release date: | 2015-03-25 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.794 Å) | Cite: | Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV. Acs Chem.Biol., 10, 2015
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6NOZ
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8JUX
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8UOB
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![BU of 8uob by Molmil](/molmil-images/mine/8uob) | SARS-CoV-2 Papain-like protease (PLpro) with Inhibitor Jun12682 | Descriptor: | 5-[2-(dimethylamino)ethoxy]-N-{(1R)-1-[(3M,5P)-3-(1-ethyl-1H-pyrazol-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-2-methylbenzamide, CHLORIDE ION, Papain-like protease nsp3, ... | Authors: | Ansari, A, Tan, B, Ruiz, F.X, Wang, J, Arnold, E. | Deposit date: | 2023-10-19 | Release date: | 2024-04-03 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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2FE8
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![BU of 2fe8 by Molmil](/molmil-images/mine/2fe8) | SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme | Descriptor: | BROMIDE ION, Replicase polyprotein 1ab, SULFATE ION, ... | Authors: | Ratia, K, Santarsiero, B.D, Mesecar, A.D. | Deposit date: | 2005-12-15 | Release date: | 2006-03-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme Proc.Natl.Acad.Sci.Usa, 103, 2006
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3E9S
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7TZJ
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![BU of 7tzj by Molmil](/molmil-images/mine/7tzj) | SARS CoV-2 PLpro in complex with inhibitor 3k | Descriptor: | DIMETHYL SULFOXIDE, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like protease, ... | Authors: | Calleja, D.J, Klemm, T, Lechtenberg, B.C, Kuchel, N.W, Lessene, G, Komander, D. | Deposit date: | 2022-02-15 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. Front Chem, 10, 2022
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4X2Z
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![BU of 4x2z by Molmil](/molmil-images/mine/4x2z) | Structural view and substrate specificity of papain-like protease from Avian Infectious Bronchitis Virus | Descriptor: | Nonstructural protein 3, ZINC ION | Authors: | Kong, L, Shaw, N, Yan, L, Lou, Z, Rao, Z. | Deposit date: | 2014-11-27 | Release date: | 2015-01-28 | Last modified: | 2015-04-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus. J.Biol.Chem., 290, 2015
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6L5T
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![BU of 6l5t by Molmil](/molmil-images/mine/6l5t) | The crystal structure of SADS-CoV Papain Like protease | Descriptor: | Peptidase C16, ZINC ION | Authors: | Fan, C.P. | Deposit date: | 2019-10-24 | Release date: | 2020-04-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural and biochemical characterization of SADS-CoV papain-like protease 2. Protein Sci., 29, 2020
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7YBG
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8G62
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![BU of 8g62 by Molmil](/molmil-images/mine/8g62) | Papain-Like Protease of SARS CoV-2 in complex with remodilin NCGC 390004 | Descriptor: | 3-methoxy-5-(1-methylpiperidin-4-yl)-N-[4-(pyrrolidine-1-sulfonyl)phenyl]benzamide, ACETATE ION, CHLORIDE ION, ... | Authors: | Osipiuk, J, Tesar, C, Endres, M, Jedrzejczak, R, Luci, D, Kales, S, Simeonov, A, Rai, G, Drayman, N, Tay, S, Oakes, S, Rosner, M, Chen, B, Dulin, N, Solway, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | Deposit date: | 2023-02-14 | Release date: | 2023-02-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Papain-Like Protease of SARS CoV-2 in complex with remodilin NCGC 390004 To Be Published
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8FWO
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![BU of 8fwo by Molmil](/molmil-images/mine/8fwo) | Crystal structure of SARS-CoV-2 papain-like protease | Descriptor: | CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Bezerra, E.H.S, Soprano, A.S, Tonoli, C.C.C, Prado, P.F.V, da Silva, J.C, Franchini, K.G, Trivella, D.B.B, Benedetti, C.E. | Deposit date: | 2023-01-23 | Release date: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of SARS-CoV-2 papain-like protease To Be Published
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3MJ5
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![BU of 3mj5 by Molmil](/molmil-images/mine/3mj5) | Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation | Descriptor: | N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Replicase polyprotein 1a, ZINC ION | Authors: | Mesecar, A.D, Ratia, K.M, Pegan, S.D. | Deposit date: | 2010-04-12 | Release date: | 2010-06-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation J.Med.Chem., 53, 2010
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3MP2
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8EUA
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![BU of 8eua by Molmil](/molmil-images/mine/8eua) | Structure of SARS-CoV2 PLpro bound to a covalent inhibitor | Descriptor: | Papain-like protease nsp3, SULFATE ION, ZINC ION, ... | Authors: | Mathews, I.I, Pokhrel, S, Wakatsuki, S. | Deposit date: | 2022-10-18 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nat Commun, 14, 2023
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8FWN
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![BU of 8fwn by Molmil](/molmil-images/mine/8fwn) | Crystal structure of SARS-CoV-2 papain-like protease C111S mutant | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Bezerra, E.H.S, Soprano, A.S, Tonoli, C.C.C, Prado, P.F.V, da Silva, J.C, Franchini, K.G, Trivella, D.B.B, Benedetti, C.E. | Deposit date: | 2023-01-23 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of SARS-CoV-2 papain-like protease C111S mutant To Be Published
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5V6A
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4R3D
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![BU of 4r3d by Molmil](/molmil-images/mine/4r3d) | Crystal structure of MERS Coronavirus papain like protease | Descriptor: | Non-structural protein 3, ZINC ION | Authors: | Kong, L.Y, Wang, Q, Ming, Z.H, Shaw, N, Sun, Y.N, Yan, L.M, Lou, Z.Y, Rao, Z.H. | Deposit date: | 2014-08-15 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.818 Å) | Cite: | The Crystal Structures of Middle East Respiratory Syndrome Coronavirus Papain-like Protease and Its Complex with an Inhibitor To be Published
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4REZ
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![BU of 4rez by Molmil](/molmil-images/mine/4rez) | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease | Descriptor: | ORF1ab protein, S-1,2-PROPANEDIOL, ZINC ION | Authors: | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | Deposit date: | 2014-09-24 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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