3E9S

A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Summary for 3E9S

• Entry DOI: 10.2210/pdb3e9s/pdb
• Related: 2FE8
• Descriptor: Non-structural protein 3, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: sars, virus, coronavirus, papain, papain-like, protease, plpro, nsp3, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger
• Biological source: SARS coronavirus (SARS-CoV)
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8
• Total number of polymer chains: 1
• Total formula weight: 36167.13

Authors

Mesecar, A.D.,Ratia, K.,Pegan, S. (deposition date: 2008-08-23, release date: 2008-10-07, Last modification date: 2011-07-13)

• Primary citation: Mesecar, A.D.,Ratia, K.,Pegan, S.; A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication; To be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)