3E9S
A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TTT A 317 |
| Chain | Residue |
| A | PRO34 |
| A | THR302 |
| A | LEU59 |
| A | GLY164 |
| A | ASP165 |
| A | PRO249 |
| A | TYR265 |
| A | TYR269 |
| A | GLN270 |
| A | TYR274 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 318 |
| Chain | Residue |
| A | CYS190 |
| A | CYS193 |
| A | CYS225 |
| A | CYS227 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 319 |
| Chain | Residue |
| A | PHE128 |
| A | HOH404 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 320 |
| Chain | Residue |
| A | PHE259 |
| A | LEU260 |
| A | LYS307 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 37 |
| Details | ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 |
| Chain | Residue | Details |
| A | CYS190-CYS227 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444 |
| Chain | Residue | Details |
| A | OCS112 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 |
| Chain | Residue | Details |
| A | HIS273 | |
| A | ASP287 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 |
| Chain | Residue | Details |
| A | CYS190 | |
| A | CYS193 | |
| A | CYS225 | |
| A | CYS227 |
