9VAO

Crystal structure of Papain-like protease (PLpro) from SARS-CoV-2

Summary for 9VAO

Entry DOI	10.2210/pdb9vao/pdb
Descriptor	Papain-like protease nsp3, ZINC ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	cysteine protease, plpro, sars-cov-2, ubl domain, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
Total number of polymer chains	1
Total formula weight	36614.56
Authors	Arya, R.,Ganesh, J.,Prashar, V.,Kumar, M. (deposition date: 2025-06-03, release date: 2025-06-18, Last modification date: 2025-12-31)
Primary citation	Arya, R.,Ganesh, J.,Prashar, V.,Kumar, M. Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro. Biol Direct, 20:102-102, 2025 Cited by PubMed Abstract: SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and immune evasion. It contains an N-terminal ubiquitin-like (Ubl) domain, whose involvement in enzymatic function remains poorly understood. PubMed: 41044763 DOI: 10.1186/s13062-025-00690-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation