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PDB: 11 results
9CUM
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BU of 9cum by Molmil
Q67H mutant of R67 DHFR complexed with Congo Red
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Dihydrofolate reductase type 2, ...
Authors:Narayana, N, Narendra, A.N.
Deposit date:2024-07-26
Release date:2025-02-19
Last modified:2025-02-26
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal structure of the plasmid-encoded R67 dihydrofolate reductase complexed with Congo red an amyloid binding dye.
Sci Rep, 15, 2025
2GQV
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BU of 2gqv by Molmil
High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site
Descriptor: Dihydrofolate reductase type 2
Authors:Narayana, N.
Deposit date:2006-04-22
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D(2)-symmetric active site.
Acta Crystallogr.,Sect.D, 62, 2006
3SFM
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BU of 3sfm by Molmil
Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2
Authors:Yachnin, B.J, Berghuis, A.M.
Deposit date:2011-06-13
Release date:2011-11-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure.
Acta Crystallogr.,Sect.F, 67, 2011
2P4T
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BU of 2p4t by Molmil
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode
Descriptor: Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Divya, N, Grifith, E, Narayana, N.
Deposit date:2007-03-13
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
Protein Sci., 16, 2007
6NY0
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BU of 6ny0 by Molmil
Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid, Dihydrofolate reductase type 2, ...
Authors:Yachnin, B.J, Berghuis, A.M.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Acs Omega, 4, 2019
6NXZ
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BU of 6nxz by Molmil
Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-[4-[(2~{R})-4-[4-(6-carboxy-1~{H}-benzimidazol-2-yl)phenoxy]-2-oxidanyl-butoxy]phenyl]-1~{H}-benzimidazole-5-carboxylic acid, Dihydrofolate reductase type 2, ...
Authors:Yachnin, B.J, Berghuis, A.M.
Deposit date:2019-02-10
Release date:2019-05-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Acs Omega, 4, 2019
1VIF
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BU of 1vif by Molmil
STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor: DIHYDROFOLATE REDUCTASE, FOLIC ACID
Authors:Narayana, N, Matthews, D.A, Howell, E.E, Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995
1VIE
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BU of 1vie by Molmil
STRUCTURE OF DIHYDROFOLATE REDUCTASE
Descriptor: DIHYDROFOLATE REDUCTASE
Authors:Narayana, N, Matthews, D.A, Howell, E.E, Xuong, N.-H.
Deposit date:1996-10-03
Release date:1997-10-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site.
Nat.Struct.Biol., 2, 1995
2RK1
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BU of 2rk1 by Molmil
DHFR R67 Complexed with NADP and dihydrofolate
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIHYDROFOLIC ACID, Dihydrofolate reductase type 2, ...
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RK2
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BU of 2rk2 by Molmil
DHFR R-67 complexed with NADP
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RH2
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BU of 2rh2 by Molmil
High Resolution DHFR R-67
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2
Authors:Krahn, J.M, London, R.E.
Deposit date:2007-10-05
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex
Biochemistry, 46, 2007

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