2P4T
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode
Summary for 2P4T
Entry DOI | 10.2210/pdb2p4t/pdb |
Related | 1VIE 1VIF 2GQV |
Descriptor | Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
Functional Keywords | bacterial infections, folate metabolism, nadp+, r67 dhfr, symmetric binding, trimethoprim-resistance, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 7485.95 |
Authors | Divya, N.,Grifith, E.,Narayana, N. (deposition date: 2007-03-13, release date: 2007-06-05, Last modification date: 2023-08-30) |
Primary citation | Divya, N.,Grifith, E.,Narayana, N. Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode. Protein Sci., 16:1063-1068, 2007 Cited by PubMed: 17473013DOI: 10.1110/ps.062740907 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.15 Å) |
Structure validation
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