2P4T
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase type 2 | polymer | 62 | 6742.5 | 1 | UniProt (P00383) Pfam (PF06442) In PDB | Escherichia coli | Dihydrofolate reductase type II |
| 2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 17 - 78 (UniProt: P00383)
| PDB | External Database | Details |
|---|---|---|
| His 67 | Gln 67 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 6742.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 743.4 | |
| All* | Total formula weight | 7486.0 |
