2CWC
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3HFW
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![BU of 3hfw by Molmil](/molmil-images/mine/3hfw) | Crystal Structure of human ADP-ribosylhydrolase 1 (hARH1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Mueller-Dieckmann, C, Weiss, M.S, Mueller-Dieckmann, J, Koch-Nolte, F. | Deposit date: | 2009-05-13 | Release date: | 2010-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Crystal Structure of human ADP-ribosylhydrolase 1 To be Published
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3G9D
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![BU of 3g9d by Molmil](/molmil-images/mine/3g9d) | Crystal structure glycohydrolase | Descriptor: | Dinitrogenase reductase activating glucohydrolase, MAGNESIUM ION | Authors: | Li, X.-D, Winkler, F.K. | Deposit date: | 2009-02-13 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Dinitrogenase Reductase-activating Glycohydrolase (DRAG) Reveals Conservation in the ADP-Ribosylhydrolase Fold and Specific Features in the ADP-Ribose-binding Pocket J.Mol.Biol., 390, 2009
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1T5J
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![BU of 1t5j by Molmil](/molmil-images/mine/1t5j) | |
2YZW
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2YZV
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5ZQY
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![BU of 5zqy by Molmil](/molmil-images/mine/5zqy) | Crystal structure of a poly(ADP-ribose) glycohydrolase | Descriptor: | MAGNESIUM ION, Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Wang, M, Yuan, Z, Ma, Y, Wang, J, Liu, X. | Deposit date: | 2018-04-20 | Release date: | 2018-08-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.577 Å) | Cite: | Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. J. Biol. Chem., 293, 2018
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7L9I
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![BU of 7l9i by Molmil](/molmil-images/mine/7l9i) | Crystal structure of human ARH3-D314A bound to magnesium and ADP-ribose | Descriptor: | ADP-ribose glycohydrolase ARH3, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Pourfarjam, Y, Kurinov, I, Moss, J, Kim, I.K. | Deposit date: | 2021-01-04 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions. J.Biol.Chem., 296, 2021
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7L9F
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![BU of 7l9f by Molmil](/molmil-images/mine/7l9f) | Crystal structure of human ARH3 bound to calcium and ADP-ribose | Descriptor: | CALCIUM ION, Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Pourfarjam, Y, Kurinov, I, Moss, J, Kim, I.K. | Deposit date: | 2021-01-04 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions. J.Biol.Chem., 296, 2021
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7L9H
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![BU of 7l9h by Molmil](/molmil-images/mine/7l9h) | Crystal structure of human ARH3-D77A bound to magnesium and ADP-ribose | Descriptor: | ADP-ribose glycohydrolase ARH3, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Pourfarjam, Y, Kurinov, I, Moss, J, Kim, I.K. | Deposit date: | 2021-01-04 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions. J.Biol.Chem., 296, 2021
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2FOZ
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![BU of 2foz by Molmil](/molmil-images/mine/2foz) | human ADP-ribosylhydrolase 3 | Descriptor: | ADP-ribosylhydrolase like 2, MAGNESIUM ION | Authors: | Mueller-Dieckmann, C, Weiss, M.S, Koch-Nolte, F. | Deposit date: | 2006-01-15 | Release date: | 2006-10-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2FP0
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![BU of 2fp0 by Molmil](/molmil-images/mine/2fp0) | human ADP-ribosylhydrolase 3 | Descriptor: | ADP-ribosylhydrolase like 2, MAGNESIUM ION | Authors: | Mueller-Dieckmann, C, Weiss, M.S, Koch-Nolte, F. | Deposit date: | 2006-01-15 | Release date: | 2006-10-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc.Natl.Acad.Sci.Usa, 103, 2006
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6D36
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![BU of 6d36 by Molmil](/molmil-images/mine/6d36) | Structure of human ARH3 bound to ADP-ribose and magnesium | Descriptor: | MAGNESIUM ION, Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Pourfarjam, Y, Ventura, J, Kurinov, I, Kim, I.K. | Deposit date: | 2018-04-14 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition. J.Biol.Chem., 293, 2018
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6D3A
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![BU of 6d3a by Molmil](/molmil-images/mine/6d3a) | Structure of human ARH3 D314E bound to ADP-ribose and magnesium | Descriptor: | MAGNESIUM ION, Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Pourfarjam, Y, Ventura, J, Kurinov, I, Kim, I.K. | Deposit date: | 2018-04-15 | Release date: | 2018-06-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.60001016 Å) | Cite: | Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition. J.Biol.Chem., 293, 2018
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2G4K
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![BU of 2g4k by Molmil](/molmil-images/mine/2g4k) | Anomalous substructure of human ADP-ribosylhydrolase 3 | Descriptor: | ADP-ribosylhydrolase 3, CHLORIDE ION, MAGNESIUM ION | Authors: | Mueller-Dieckmann, C, Weiss, M.S. | Deposit date: | 2006-02-22 | Release date: | 2007-02-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths. Acta Crystallogr.,Sect.D, 63, 2007
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7AQM
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![BU of 7aqm by Molmil](/molmil-images/mine/7aqm) | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with alpha-1''-O-methyl-ADP-ribose (meADPr) | Descriptor: | ADP-ribosylhydrolase like 2, Adenosine 5'-diphosphoric acid beta-[(3beta,4beta-dihydroxy-5beta-methoxytetrahydrofuran-2alpha-yl)methyl] estere, MAGNESIUM ION | Authors: | Rack, J.G.M, Zorzini, V, Ahel, I. | Deposit date: | 2020-10-22 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun, 12, 2021
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7AKR
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7AKS
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7ARW
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![BU of 7arw by Molmil](/molmil-images/mine/7arw) | Structure of human ARH3 E41A bound to alpha-NAD+ and magnesium | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADP-ribose glycohydrolase ARH3, ... | Authors: | Rack, J.G.M, Zorzini, V, Ahel, I. | Deposit date: | 2020-10-26 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun, 12, 2021
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2WOE
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![BU of 2woe by Molmil](/molmil-images/mine/2woe) | Crystal Structure of the D97N variant of dinitrogenase reductase- activating glycohydrolase (DRAG) from Rhodospirillum rubrum in complex with ADP-ribose | Descriptor: | ADP-RIBOSYL-[DINITROGEN REDUCTASE] GLYCOHYDROLASE, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Berthold, C.L, Wang, H, Nordlund, S, Hogbom, M. | Deposit date: | 2009-07-23 | Release date: | 2009-08-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of Adp-Ribosylation Removal Revealed by the Structure and Ligand Complexes of the Dimanganese Mono-Adp-Ribosylhydrolase Drag. Proc.Natl.Acad.Sci.USA, 106, 2009
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2WOD
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![BU of 2wod by Molmil](/molmil-images/mine/2wod) | Crystal Structure of the dinitrogenase reductase-activating glycohydrolase (DRAG) from Rhodospirillum rubrum in complex with ADP- ribsoyllysine | Descriptor: | ADP-RIBOSYL-[DINITROGEN REDUCTASE] GLYCOHYDROLASE, CHLORIDE ION, GLYCEROL, ... | Authors: | Berthold, C.L, Wang, H, Nordlund, S, Hogbom, M. | Deposit date: | 2009-07-23 | Release date: | 2009-08-11 | Last modified: | 2018-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Mechanism of Adp-Ribosylation Removal Revealed by the Structure and Ligand Complexes of the Dimanganese Mono-Adp-Ribosylhydrolase Drag. Proc.Natl.Acad.Sci.USA, 106, 2009
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2QTY
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2WOC
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![BU of 2woc by Molmil](/molmil-images/mine/2woc) | Crystal Structure of the dinitrogenase reductase-activating glycohydrolase (DRAG) from Rhodospirillum rubrum | Descriptor: | ADP-RIBOSYL-[DINITROGEN REDUCTASE] GLYCOHYDROLASE, CHLORIDE ION, FORMIC ACID, ... | Authors: | Berthold, C.L, Wang, H, Nordlund, S, Hogbom, M. | Deposit date: | 2009-07-23 | Release date: | 2009-08-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of Adp-Ribosylation Removal Revealed by the Structure and Ligand Complexes of the Dimanganese Mono-Adp-Ribosylhydrolase Drag. Proc.Natl.Acad.Sci.USA, 106, 2009
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6G1Q
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![BU of 6g1q by Molmil](/molmil-images/mine/6g1q) | ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribose | Descriptor: | ADP-ribosylhydrolase like 2, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Ariza, A. | Deposit date: | 2018-03-21 | Release date: | 2018-11-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell Chem Biol, 25, 2018
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6G28
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![BU of 6g28 by Molmil](/molmil-images/mine/6g28) | Human [protein ADP-ribosylargenine] hydrolase ARH1 in complex with ADP-ribose | Descriptor: | CHLORIDE ION, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... | Authors: | Ariza, A. | Deposit date: | 2018-03-22 | Release date: | 2018-11-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell Chem Biol, 25, 2018
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