6D3A

Structure of human ARH3 D314E bound to ADP-ribose and magnesium

Summary for 6D3A

Entry DOI	10.2210/pdb6d3a/pdb
Descriptor	Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	poly(adp-ribose) hydrolase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	159502.44
Authors	Pourfarjam, Y.,Ventura, J.,Kurinov, I.,Kim, I.K. (deposition date: 2018-04-15, release date: 2018-06-20, Last modification date: 2024-03-13)
Primary citation	Pourfarjam, Y.,Ventura, J.,Kurinov, I.,Cho, A.,Moss, J.,Kim, I.K. Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition. J.Biol.Chem., 293:12350-12359, 2018 Cited by PubMed: 29907568 DOI: 10.1074/jbc.RA118.003586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.60001013785 Å)

Structure validation