7L9F

Crystal structure of human ARH3 bound to calcium and ADP-ribose

Summary for 7L9F

Entry DOI	10.2210/pdb7l9f/pdb
Descriptor	Poly(ADP-ribose) glycohydrolase ARH3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, CALCIUM ION, ... (4 entities in total)
Functional Keywords	adp-ribose, calcium, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	159669.73
Authors	Pourfarjam, Y.,Kurinov, I.,Moss, J.,Kim, I.K. (deposition date: 2021-01-04, release date: 2021-04-28, Last modification date: 2023-10-18)
Primary citation	Pourfarjam, Y.,Ma, Z.,Kurinov, I.,Moss, J.,Kim, I.K. Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions. J.Biol.Chem., 296:100692-100692, 2021 Cited by PubMed: 33894202 DOI: 10.1016/j.jbc.2021.100692 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation