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PDB: 210 results

8PKV
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BU of 8pkv by Molmil
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDEETGEC).
Descriptor: (2-methylphenyl)methanol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Braun, M.B, Bischof, L, Hartmann, M.D.
Deposit date:2023-06-27
Release date:2023-11-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Computational Prediction of Cyclic Peptide Structural Ensembles and Application to the Design of Keap1 Binders.
J.Chem.Inf.Model., 63, 2023
8PKS
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BU of 8pks by Molmil
Low resolution crystal structure of Keap1-456, a repeat fragment from the human Keap1 beta-propeller
Descriptor: Kelch-like ECH-associated protein 1
Authors:Wouters, S.M.L.
Deposit date:2023-06-27
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Fragment-based assembly of a symmetric protein scaffold
To Be Published
8Q1Q
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BU of 8q1q by Molmil
mouse Keap1 in complex with stapled peptide
Descriptor: Kelch-like ECH-associated protein 1, SULFATE ION, Stapled peptide, ...
Authors:Kack, H, Wissler, L.
Deposit date:2023-08-01
Release date:2023-10-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.378 Å)
Cite:A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction.
Chem Sci, 14, 2023
8Q1R
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BU of 8q1r by Molmil
mouse Keap1 in complex with stapled peptide
Descriptor: Kelch-like ECH-associated protein 1, SODIUM ION, SULFATE ION, ...
Authors:Kack, H, Wissler, L.
Deposit date:2023-08-01
Release date:2023-10-25
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction.
Chem Sci, 14, 2023
6T7Z
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BU of 6t7z by Molmil
KEAP1 IN COMPLEX WITH COMPOUND 44
Descriptor: ACE-CYS-ASA-4FB-GLU-THR-GLY-GLU-CYS-NH2, ACETATE ION, Kelch-like ECH-associated protein 1
Authors:Colarusso, S.
Deposit date:2019-10-23
Release date:2020-09-09
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg.Med.Chem., 28, 2020
6T7V
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BU of 6t7v by Molmil
KEAP1 IN COMPLEX WITH PEPTIDE 8
Descriptor: ACETATE ION, Kelch-like ECH-associated protein 1, LEU-ASP-PRO-GLU-THR-GLY-GLU-PHE-LEU
Authors:Colarusso, S.
Deposit date:2019-10-23
Release date:2020-09-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg.Med.Chem., 28, 2020
6TG8
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BU of 6tg8 by Molmil
Crystal structure of the Kelch domain in complex with 11 amino acid peptide (model of the ETGE loop)
Descriptor: Kelch-like ECH-associated protein 1, SODIUM ION, VAL-ILE-ASN-PRO-GLU-THR-GLY-GLU-GLN-ILE-GLN
Authors:Kekez, I, Matic, S, Tomic, S, Matkovic-Calogovic, D.
Deposit date:2019-11-15
Release date:2020-09-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process.
J.Biomol.Struct.Dyn., 39, 2021
6TTK
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BU of 6ttk by Molmil
Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DVL1, ...
Authors:Chen, Z, Williams, E, Pike, A.C.W, Strain-Damerell, C, Wang, D, Chalk, R, Burgess-Brown, N, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
Deposit date:2019-12-27
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.383 Å)
Cite:Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Open Biology, 10, 2020
6TYM
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BU of 6tym by Molmil
KEAP1 Kelch domain in complex with Compound 9
Descriptor: (3S)-3-[2-(benzenecarbonyl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Marcotte, D.J.
Deposit date:2019-08-09
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.422 Å)
Cite:Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Bioorg.Med.Chem.Lett., 30, 2020
6TYP
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BU of 6typ by Molmil
KEAP1 Kelch domain in complex with Compound 2
Descriptor: (3S)-3-[2-(benzenecarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid, FORMIC ACID, Kelch-like ECH-associated protein 1
Authors:Marcotte, D.J.
Deposit date:2019-08-09
Release date:2020-01-15
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Bioorg.Med.Chem.Lett., 30, 2020
5WFL
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BU of 5wfl by Molmil
Kelch domain of human Keap1 in open unliganded conformation
Descriptor: Kelch-like ECH-associated protein 1, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-12
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
5YQ4
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BU of 5yq4 by Molmil
Crystal structure of kelch domain of KLHL20
Descriptor: Kelch-like protein 20
Authors:Yeh, M.C, Ho, M.C.
Deposit date:2017-11-05
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The crystal structure of kelch domain of KLHL20
To Be Published
6V6Z
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BU of 6v6z by Molmil
Crystal structure of N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine bound to human Keap1 Kelch domain
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DITHIANE DIOL, FORMIC ACID, ...
Authors:Lazzara, P.R, David, B.P, Ankireddy, A, Richardson, B.G, Dye, K, Ratia, K.M, Reddy, S.P, Moore, T.W.
Deposit date:2019-12-06
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.
Acs Med.Chem.Lett., 11, 2020
5WHL
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BU of 5whl by Molmil
Kelch domain of human Keap1 bound to inhibitory small molecule fragment: hydroxyphenyl propionic acid
Descriptor: HYDROXYPHENYL PROPIONIC ACID, Kelch-like ECH-associated protein 1, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-17
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
5WIY
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BU of 5wiy by Molmil
Kelch domain of human Keap1 bound to small molecule inhibitor fragment: 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione
Descriptor: 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione, Kelch-like ECH-associated protein 1, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-20
Release date:2018-09-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
6V7O
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BU of 6v7o by Molmil
Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex
Descriptor: Dvl3-peptide, Kelch-like protein 12
Authors:Zhao, B.
Deposit date:2019-12-09
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.
Biochemistry, 59, 2020
6UF0
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BU of 6uf0 by Molmil
Crystal structure of N-(4-((4-methoxy-N-(2,2,2-trifluoroethyl)phenyl)sulfonamido)isoquinolin-1-yl)-N-((4-methoxyphenyl)sulfonyl)glycine bound to human Keap1 Kelch domain
Descriptor: DIMETHYL SULFOXIDE, FORMIC ACID, Kelch-like ECH-associated protein 1, ...
Authors:Lazzara, P.R, David, B.P, Ankireddy, A, Richardson, B.G, Dye, K, Ratia, K.M, Reddy, S.P, Moore, T.W.
Deposit date:2019-09-23
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
J.Med.Chem., 63, 2020
5WFV
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BU of 5wfv by Molmil
Kelch domain of human Keap1 bound to Nrf2 ETGE peptide
Descriptor: Kelch-like ECH-associated protein 1, Nrf2 ETGE peptide, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-12
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
5WHO
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BU of 5who by Molmil
Kelch domain of human Keap1 bound to small molecule inhibitor fragment: 4-oxo-4H-1-benzopyran-2-carboxylic acid
Descriptor: 4-oxo-4H-1-benzopyran-2-carboxylic acid, Kelch-like ECH-associated protein 1, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-17
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
5X54
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BU of 5x54 by Molmil
Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide
Descriptor: ACE-GLU-TRP-TRP-TRP, ACETATE ION, Kelch-like ECH-associated protein 1
Authors:Sogabe, S, Kadotani, A, Lane, W, Snell, G.
Deposit date:2017-02-14
Release date:2017-03-29
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization
Biochem. Biophys. Res. Commun., 486, 2017
5WG1
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BU of 5wg1 by Molmil
Kelch domain of human Keap1 bound to mutant Nrf2 EAGE peptide
Descriptor: Kelch-like ECH-associated protein 1, Nrf2 EAGE mutant peptide, SULFATE ION
Authors:Carolan, J.P, Lynch, A.J, Allen, K.N.
Deposit date:2017-07-13
Release date:2018-09-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.021 Å)
Cite:Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59, 2020
5YY8
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BU of 5yy8 by Molmil
Crystal structure of the Kelch domain of human NS1-BP
Descriptor: Influenza virus NS1A-binding protein
Authors:Guo, L, Liu, Y, Liang, H.
Deposit date:2017-12-08
Release date:2018-03-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 angstrom resolution.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5F72
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BU of 5f72 by Molmil
De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Descriptor: Kelch-like ECH-associated protein 1, Single chain Fv from a Fab
Authors:Liu, X, Taylor, R.D, Griffin, L, Coker, S, Adams, R, Ceska, T, Shi, J, Lawson, A.D.G, Baker, T.
Deposit date:2015-12-07
Release date:2016-12-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
To Be Published
5FNQ
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BU of 5fnq by Molmil
Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.
Descriptor: 3-(4-CHLOROPHENYL)PROPANOIC ACID, KELCH-LIKE ECH-ASSOCIATED PROTEIN 1
Authors:Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FZN
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BU of 5fzn by Molmil
Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.
Descriptor: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, SULFATE ION, benzenesulfonamide
Authors:Davies, T.G, Wixted, W.E, Coyle, J.E, Griffiths-Jones, C, Hearn, K, McMenamin, R, Norton, D, Rich, S.J, Richardson, C, Saxty, G, Willems, H.M.G, Woolford, A.J, Cottom, J.E, Kou, J, Yonchuk, J.G, Feldser, H.G, Sanchez, Y, Foley, J.P, Bolognese, B.J, Logan, G, Podolin, P.L, Yan, H, Callahan, J.F, Heightman, T.D, Kerns, J.K.
Deposit date:2016-03-15
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016

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PDB entries from 2024-11-13

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