Summary for 5FNQ
| Related | 5FNR 5FNS 5FNT 5FNU |
|---|---|
| Descriptor | KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, 3-(4-CHLOROPHENYL)PROPANOIC ACID (3 entities in total) |
| Functional Keywords | transcription, keap1, nrf2, oxidative stress |
| Biological source | MUS MUSCULUS (HOUSE MOUSE) |
| Cellular location | Cytoplasm Q9Z2X8 |
| Total number of polymer chains | 1 |
| Total molecular weight | 33546.92 |
| Authors | Davies, T.G.,Wixted, W.E.,Coyle, J.E.,Griffiths-Jones, C.,Hearn, K.,McMenamin, R.,Norton, D.,Rich, S.J.,Richardson, C.,Saxty, G.,Willems, H.M.G.,Woolford, A.J.,Cottom, J.E.,Kou, J.,Yonchuk, J.G.,Feldser, H.G.,Sanchez, Y.,Foley, J.P.,Bolognese, B.J.,Logan, G.,Podolin, P.L.,Yan, H.,Callahan, J.F.,Heightman, T.D.,Kerns, J.K. (deposition date: 2015-11-16, release date: 2016-04-13, Last modification date: 2018-04-04) |
| Primary citation | Davies, T.G.,Wixted, W.E.,Coyle, J.E.,Griffiths-Jones, C.,Hearn, K.,Mcmenamin, R.L.,Norton, D.,Rich, S.J.,Richardson, C.,Saxty, G.,Willems, H.M.G.,Woolford, A.J.,Cottom, J.E.,Kou, J.,Yonchuk, J.G.,Feldser, H.G.,Sanchez, Y.,Foley, J.P.,Bolognese, B.J.,Logan, G.A.,Podolin, P.L.,Yan, H.,Callahan, J.F.,Heightman, T.D.,Kerns, J.K. Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J.Med.Chem., 59:3991-, 2016 PubMed: 27031670 (PDB entries with the same primary citation) DOI: 10.1021/ACS.JMEDCHEM.6B00228  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.91 Å) |
