5FNQ

Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE S0W A 1614

Chain	Residue
A	ARG415
A	PHE478
A	ARG483
A	SER508
A	GLY509
A	ALA556

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Sensor for electrophilic agents => ECO:0000269|PubMed:20498371

Chain	Residue	Details
A	CYS434

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-cGMP-cysteine => ECO:0000269|PubMed:20498371

Chain	Residue	Details
A	CYS434

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: S-(2-succinyl)cysteine => ECO:0000269|PubMed:22014577

Chain	Residue	Details
A	CYS613

---