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5WG1

Kelch domain of human Keap1 bound to mutant Nrf2 EAGE peptide

Summary for 5WG1
Entry DOI10.2210/pdb5wg1/pdb
DescriptorKelch-like ECH-associated protein 1, Nrf2 EAGE mutant peptide, SULFATE ION, ... (4 entities in total)
Functional Keywordsscaffold, peptide-bound, transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight75012.54
Authors
Carolan, J.P.,Lynch, A.J.,Allen, K.N. (deposition date: 2017-07-13, release date: 2018-09-19, Last modification date: 2023-10-04)
Primary citationZhong, M.,Lynch, A.,Muellers, S.N.,Jehle, S.,Luo, L.,Hall, D.R.,Iwase, R.,Carolan, J.P.,Egbert, M.,Wakefield, A.,Streu, K.,Harvey, C.M.,Ortet, P.C.,Kozakov, D.,Vajda, S.,Allen, K.N.,Whitty, A.
Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).
Biochemistry, 59:563-581, 2020
Cited by
PubMed: 31851823
DOI: 10.1021/acs.biochem.9b00943
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.021 Å)
Structure validation

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