6DT7
 
 | | Bacteriophage N4 RNA polymerase II and DNA complex | | Descriptor: | DNA (5'-D(P*CP*CP*AP*CP*CP*TP*GP*CP*A)-3'), RNAP1, RNAP2 | | Authors: | Molodtsov, V, Murakami, K.S. | | Deposit date: | 2018-06-15 | | Release date: | 2018-07-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
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6DT8
 | | Bacteriophage N4 RNA polymerase II elongation complex 1 | | Descriptor: | DNA (5'-D(P*AP*CP*CP*CP*AP*CP*CP*AP*AP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*UP*GP*G)-3'), RNAP1, ... | | Authors: | Molodtsov, V, Murakami, K.S. | | Deposit date: | 2018-06-15 | | Release date: | 2018-07-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
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6DTA
 | | Bacteriophage N4 RNA polymerase II elongation complex 2 | | Descriptor: | DNA (5'-D(P*CP*CP*CP*AP*CP*CP*AP*AP*AP*AP*A)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Molodtsov, V, Murakami, K.S. | | Deposit date: | 2018-06-15 | | Release date: | 2018-07-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.694 Å) | | Cite: | Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
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1MSW
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4RNP
 | | BACTERIOPHAGE T7 RNA POLYMERASE, HIGH SALT CRYSTAL FORM, LOW TEMPERATURE DATA, ALPHA-CARBONS ONLY | | Descriptor: | RNA POLYMERASE | | Authors: | Liu, Z.J, Sousa, R, Rose, J.P, Wang, B.C. | | Deposit date: | 1997-09-11 | | Release date: | 1997-12-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of bacteriophage T7 RNA polymerase at 3.3 A resolution.
Nature, 364, 1993
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5OLA
 | | Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM | | Descriptor: | DNA (30-MER), DNA (5'-D(P*AP*TP*GP*GP*TP*GP*TP*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*GP*AP*AP*C)-3'), DNA-directed RNA polymerase, ... | | Authors: | Hillen, H.S, Parshin, A.V, Agaronyan, K, Morozov, Y, Graber, J.J, Chernev, A, Schwinghammer, K, Urlaub, H, Anikin, M, Cramer, P, Temiakov, D. | | Deposit date: | 2017-07-27 | | Release date: | 2017-10-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.904 Å) | | Cite: | Mechanism of Transcription Anti-termination in Human Mitochondria.
Cell, 171, 2017
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7PZR
 | | Cryo-EM structure of POLRMT in free form. | | Descriptor: | DNA-directed RNA polymerase, mitochondrial | | Authors: | Das, H, Hallberg, B.M. | | Deposit date: | 2021-10-13 | | Release date: | 2022-11-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization.
Cell, 185, 2022
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7A8P
 | | Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. | | Descriptor: | (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid, DNA-directed RNA polymerase, mitochondrial | | Authors: | Hillen, H.S, Bonekamp, N, Peter, B, Felser, A, Bergbrede, T, Choidas, A, Horn, M, Unger, A, di Lucrezia, R, Atanassov, I, Li, X, Koch, U, Menninger, S, Boros, J, Habenberger, P, Giavalisco, P, Cramer, P, Denzel, M, Nussbaumer, P, Klebl, B, Falkenberg, M, Gustafsson, C.M, Larsson, N.G. | | Deposit date: | 2020-08-30 | | Release date: | 2020-12-30 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Small-molecule inhibitors of human mitochondrial DNA transcription.
Nature, 588, 2020
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4BOC
 | | Structure of mitochondrial RNA polymerase elongation complex | | Descriptor: | 5'-D(*CP*AP*TP*GP*GP*GP*GP*TP*AP*AP*TP*TP*AP*TP *TP*TP*CP*GP*AP*CP*GP*CP*CP*AP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*TP*GP*GP*CP*GP*TP*GP*CP*GP*CP *GP*CP*CP*GP*CP*TP*AP*CP*CP*CP*CP*AP*TP*G)-3', 5'-R(*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP)-3', ... | | Authors: | Schwinghammer, K, Cheung, A, Morozov, Y, Agaronyan, K, Temiakov, D, Cramer, P. | | Deposit date: | 2013-05-18 | | Release date: | 2013-09-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structure of Human Mitochondrial RNA Polymerase Elongation Complex
Nat.Struct.Mol.Biol., 20, 2013
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1H38
 | | Structure of a T7 RNA polymerase elongation complex at 2.9A resolution | | Descriptor: | 5'-D(*GP*GP*GP*AP*AP*TP*CP*GP*AP*CP *AP*TP*CP*GP*CP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*AP*TP*TP*CP*CP*CP)-3', 5'-R(*AP*AP*CP*UP*GP*CP*GP*GP*CP*GP *AP*U)-3', ... | | Authors: | Tahirov, T.H, Temyakov, D, Anikin, M, Patlan, V, McAllister, W.T, Vassylyev, D.G, Yokoyama, S. | | Deposit date: | 2002-08-24 | | Release date: | 2002-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of a T7 RNA Polymerase Elongation Complex at 2.9 A Resolution
Nature, 420, 2002
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7PZP
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7ZC4
 | | Cryo-EM structure of POLRMT mutant. | | Descriptor: | DNA-directed RNA polymerase, mitochondrial | | Authors: | Das, H, Hallberg, B.M. | | Deposit date: | 2022-03-25 | | Release date: | 2023-02-01 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization.
Cell, 185, 2022
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1QLN
 | | STRUCTURE OF A TRANSCRIBING T7 RNA POLYMERASE INITIATION COMPLEX | | Descriptor: | BACTERIOPHAGE T7 RNA POLYMERASE, DNA (5- D (P*CP*TP*CP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP* AP*TP*TP*A)-3), DNA (5-D(P*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*TP*A)-3), ... | | Authors: | Cheetham, G.M.T, Steitz, T.A. | | Deposit date: | 1999-09-01 | | Release date: | 2000-02-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of a Transcribing T7 RNA Polymerase Initiation Complex
Science, 286, 1999
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3SPA
 | | Crystal Structure of Human Mitochondrial RNA Polymerase | | Descriptor: | CHLORIDE ION, DNA-directed RNA polymerase, mitochondrial, ... | | Authors: | Ringel, R, Sologub, M, Morozov, Y.I, Litonin, D, Cramer, P, Temiakov, D. | | Deposit date: | 2011-07-01 | | Release date: | 2011-09-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of human mitochondrial RNA polymerase
Nature, 478, 2011
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8U8V
 | | Cryo-EM structure of Substrate ATP Bound in the Insertion Site (IS) of Human Mitochondrial Transcription Elongation Complex | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | Authors: | Herbine, K.H, Nayak, A.R, Temiakov, D. | | Deposit date: | 2023-09-18 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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8U8U
 | | Cryo-EM Structure of Cognate Substrate ATP Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | Authors: | Herbine, K.H, Nayak, A.R, Temiakov, D. | | Deposit date: | 2023-09-18 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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9BDC
 | | Cryo-EM Structure of the TEFM-bound Human Mitochondrial Transcription Substrate Rejection Complex | | Descriptor: | DNA-directed RNA polymerase, mitochondrial, Non-Template Strand DNA (NT27mt_+1T), ... | | Authors: | Herbine, K.H, Nayak, A.R, Temiakov, D. | | Deposit date: | 2024-04-11 | | Release date: | 2024-09-04 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (2.54 Å) | | Cite: | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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9BDD
 | | Cryo-EM Structure of Non-Cognate Substrate Bound in the Entry Site (ES) of Human Mitochondrial Transcription Elongation Complex | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-directed RNA polymerase, mitochondrial, ... | | Authors: | Herbine, K.H, Nayak, A.R, Temiakov, D. | | Deposit date: | 2024-04-11 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
Nat Commun, 15, 2024
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3E3J
 | | Crystal Structure of an Intermediate Complex of T7 RNAP and 8nt of RNA | | Descriptor: | DNA (28-MER), DNA (5'-D(*DTP*DAP*DAP*DTP*DAP*DCP*DGP*DAP*DCP*DTP*DCP*DAP*DCP*DTP*DAP*DTP*DAP*DTP*DTP*DTP*DCP*DTP*DGP*DCP*DCP*DAP*DAP*DAP*DCP*DGP*DGP*DC)-3'), DNA-directed RNA polymerase, ... | | Authors: | Durniak, K.J, Bailey, S, Steitz, T.A. | | Deposit date: | 2008-08-07 | | Release date: | 2008-11-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (6.7 Å) | | Cite: | The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Science, 322, 2008
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1CEZ
 | | CRYSTAL STRUCTURE OF A T7 RNA POLYMERASE-T7 PROMOTER COMPLEX | | Descriptor: | DNA (5'-D(P*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*TP*A)-3'), DNA (5'-D(P*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3'), PROTEIN (BACTERIOPHAGE T7 RNA POLYMERASE) | | Authors: | Cheetham, G.M.T, Jeruzalmi, D, Steitz, T.A. | | Deposit date: | 1999-03-11 | | Release date: | 1999-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for initiation of transcription from an RNA polymerase-promoter complex.
Nature, 399, 1999
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2PI5
 | | T7 RNA polymerase complexed with a phi10 promoter | | Descriptor: | 5'-D(*CP*TP*TP*C*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', DNA-directed RNA polymerase | | Authors: | Kennedy, W.P, Momand, J.R, Yin, Y.W. | | Deposit date: | 2007-04-12 | | Release date: | 2007-06-19 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
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3E2E
 | | Crystal Structure of an Intermediate Complex of T7 RNAP and 7nt of RNA | | Descriptor: | DNA (28-MER), DNA (31-MER), DNA-directed RNA polymerase, ... | | Authors: | Durniak, K.J, Bailey, S, Steitz, T.A. | | Deposit date: | 2008-08-05 | | Release date: | 2008-11-04 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Science, 322, 2008
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1ARO
 | | T7 RNA POLYMERASE COMPLEXED WITH T7 LYSOZYME | | Descriptor: | MERCURY (II) ION, T7 LYSOZYME, T7 RNA POLYMERASE | | Authors: | Steitz, T, Jeruzalmi, D. | | Deposit date: | 1997-08-08 | | Release date: | 1998-10-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme.
EMBO J., 17, 1998
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2PI4
 | | T7RNAP complexed with a phi10 protein and initiating GTPs. | | Descriptor: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', ... | | Authors: | Kennedy, W.P, Momand, J.R, Yin, Y.W. | | Deposit date: | 2007-04-12 | | Release date: | 2007-06-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
J.Mol.Biol., 370, 2007
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1S77
 | | T7 RNAP product pyrophosphate elongation complex | | Descriptor: | DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), DNA-directed RNA polymerase, ... | | Authors: | Yin, Y.W, Steitz, T.A. | | Deposit date: | 2004-01-29 | | Release date: | 2004-03-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Cell(Cambridge,Mass.), 116, 2004
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