4U4I
| Megavirus chilensis superoxide dismutase | Descriptor: | Cu/Zn superoxide dismutase | Authors: | Lartigue, A, Claverie, J.-M, Burlat, B, Coutard, B, Abergel, C. | Deposit date: | 2014-07-23 | Release date: | 2014-11-05 | Last modified: | 2014-12-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The megavirus chilensis cu,zn-superoxide dismutase: the first viral structure of a typical cellular copper chaperone-independent hyperstable dimeric enzyme. J.Virol., 89, 2015
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7NXX
| Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2). | Descriptor: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION, ... | Authors: | Gallardo, R, Rousseau, F, Schymkowitz, J, Ulens, C. | Deposit date: | 2021-03-19 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.189 Å) | Cite: | Identification and rational improvement of a nanobody that suppresses aggregation of mutant SOD1 To Be Published
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8Q6M
| Human SOD1 low dose data collecton | Descriptor: | ACETATE ION, COPPER (II) ION, SULFATE ION, ... | Authors: | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | Deposit date: | 2023-08-14 | Release date: | 2023-12-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS. Plos Biol., 22, 2024
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4XCR
| Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Wang, H, Logan, D.T, Danielsson, J, Mu, X, Binolfi, A, Theillet, F, Bekei, B, Lang, L, Wennerstrom, H, Selenko, P, Oliveberg, M. | Deposit date: | 2014-12-18 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.602 Å) | Cite: | Thermodynamics of protein destabilization in live cells. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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8CCX
| Human SOD1 in complex with S-XL6 cross-linker | Descriptor: | COPPER (II) ION, DIMETHYL SULFOXIDE, SULFATE ION, ... | Authors: | Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S. | Deposit date: | 2023-01-27 | Release date: | 2023-12-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.665 Å) | Cite: | Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS. Plos Biol., 22, 2024
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5CU9
| CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO | Descriptor: | Cell surface Cu-only superoxide dismutase 5, SULFATE ION | Authors: | Waninger-Saroni, J.J, Taylor, A.B, Hart, P.J, Galaleldeen, A. | Deposit date: | 2015-07-24 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO To Be Published
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6SPA
| A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, SULFATE ION, ... | Authors: | Shahid, M, Chantadul, V, Amporndanai, K, Wright, G, Antonyuk, S, Hasnain, S. | Deposit date: | 2019-08-31 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy. Commun Biol, 3, 2020
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4FF9
| Crystal Structure of cysteinylated WT SOD1. | Descriptor: | COPPER (II) ION, CYSTEINE, Superoxide dismutase [Cu-Zn], ... | Authors: | Auclair, J.R, Brodkin, H.R, D'Aquino, J.A, Ringe, D, Petsko, G.A, Agar, J.N. | Deposit date: | 2012-05-31 | Release date: | 2013-09-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5003 Å) | Cite: | Structural consequences of cysteinylation of cu/zn-superoxide dismutase. Biochemistry, 52, 2013
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5O40
| SOD1 bound to Ebselen | Descriptor: | N-phenyl-2-selanylbenzamide, SULFATE ION, Superoxide dismutase [Cu-Zn], ... | Authors: | Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. | Deposit date: | 2017-05-25 | Release date: | 2018-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nat Commun, 9, 2018
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5O3Y
| SOD1 bound to Ebsulfur | Descriptor: | SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ... | Authors: | Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S. | Deposit date: | 2017-05-25 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nat Commun, 9, 2018
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6ZS1
| Chaetomium thermophilum CuZn-superoxide dismutase | Descriptor: | COPPER (II) ION, GLYCEROL, PHOSPHATE ION, ... | Authors: | Papageorgiou, A.C, Mohsin, I. | Deposit date: | 2020-07-15 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Crystal Structure of a Cu,Zn Superoxide Dismutase From the Thermophilic Fungus Chaetomium thermophilum. Protein Pept.Lett., 28, 2021
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7B4O
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7B4P
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7CJW
| Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a crowded environment | Descriptor: | Monomeric Human Cu,Zn Superoxide dismutase | Authors: | Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K. | Deposit date: | 2020-07-14 | Release date: | 2021-05-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel. J.Phys.Chem.B, 125, 2021
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7CJV
| Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a dilute environment | Descriptor: | Monomeric Human Cu,Zn Superoxide dismutase | Authors: | Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K. | Deposit date: | 2020-07-14 | Release date: | 2021-05-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel. J.Phys.Chem.B, 125, 2021
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4N3T
| Candida albicans Superoxide Dismutase 5 (SOD5), Cu(I) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COPPER (I) ION, Potential secreted Cu/Zn superoxide dismutase, ... | Authors: | Galaleldeen, A, Taylor, A.B, Waninger-Saroni, J.J, Holloway, S.P, Hart, P.J. | Deposit date: | 2013-10-07 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc.Natl.Acad.Sci.USA, 111, 2014
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5K02
| Structure of human SOD1 with T2D mutation | Descriptor: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION | Authors: | Fay, J.M, Zhu, C, Cui, W, Ke, H, Dokholyan, N.V. | Deposit date: | 2016-05-17 | Release date: | 2016-11-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation. Structure, 24, 2016
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5KBL
| Candida Albicans Superoxide Dismutase 5 (SOD5), E110Q Mutant | Descriptor: | COPPER (I) ION, Cell surface Cu-only superoxide dismutase 5, SULFATE ION | Authors: | Galaleldeen, A, Peterson, R.L, Villarreal, J, Taylor, A.B, Hart, P.J. | Deposit date: | 2016-06-03 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.414 Å) | Cite: | The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J.Biol.Chem., 291, 2016
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5KBM
| Candida Albicans Superoxide Dismutase 5 (SOD5), D113N Mutant | Descriptor: | COPPER (I) ION, Cell surface Cu-only superoxide dismutase 5, SULFATE ION | Authors: | Galaleldeen, A, Peterson, R.L, Villarreal, J, Taylor, A.B, Hart, P.J. | Deposit date: | 2016-06-03 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.416 Å) | Cite: | The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J.Biol.Chem., 291, 2016
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8GSQ
| Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. | Descriptor: | (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Superoxide dismutase [Cu-Zn], ... | Authors: | Aouti, S, Padmanabhan, B. | Deposit date: | 2022-09-06 | Release date: | 2023-06-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis. Acta Crystallogr D Struct Biol, 79, 2023
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5KBK
| Candida Albicans Superoxide Dismutase 5 (SOD5), E110A Mutant | Descriptor: | COPPER (I) ION, Cell surface Cu-only superoxide dismutase 5, SULFATE ION | Authors: | Galaleldeen, A, Peterson, R.L, Villarreal, J, Taylor, A.B, Hart, P.J. | Deposit date: | 2016-06-03 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.411 Å) | Cite: | The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J.Biol.Chem., 291, 2016
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4OH2
| Crystal Structure of Cu/Zn Superoxide Dismutase I149T | Descriptor: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION | Authors: | Crane, B.R, Merz, G.E. | Deposit date: | 2014-01-16 | Release date: | 2014-10-15 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.384 Å) | Cite: | Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States. Biophys.J., 107, 2014
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4OJA
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8IQ1
| Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ... | Authors: | Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C. | Deposit date: | 2023-03-15 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Rep, 42, 2023
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8IQ0
| Crystal structure of hydrogen sulfide-bound superoxide dismutase in oxidized state | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ... | Authors: | Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C. | Deposit date: | 2023-03-15 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Rep, 42, 2023
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