8CCX

Human SOD1 in complex with S-XL6 cross-linker

Summary for 8CCX

• Entry DOI: 10.2210/pdb8ccx/pdb
• Descriptor: Superoxide dismutase [Cu-Zn], COPPER (II) ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: sod1, amyotrophic lateral sclerosis, als, pharmacological chaperone, cross-linking, stabilization, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 32698.75

Authors

Antonyuk, S.V.,Hossain, A.,Agar, J.N.,Hasnain, S.S. (deposition date: 2023-01-27, release date: 2023-12-13, Last modification date: 2024-02-07)

• Primary citation: Hossain, M.A.,Sarin, R.,Donnelly, D.P.,Miller, B.C.,Weiss, A.,McAlary, L.,Antonyuk, S.V.,Salisbury, J.P.,Amin, J.,Conway, J.B.,Watson, S.S.,Winters, J.N.,Xu, Y.,Alam, N.,Brahme, R.R.,Shahbazian, H.,Sivasankar, D.,Padmakumar, S.,Sattarova, A.,Ponmudiyan, A.C.,Gawde, T.,Verrill, D.E.,Yang, W.,Kannapadi, S.,Plant, L.D.,Auclair, J.R.,Makowski, L.,Petsko, G.A.,Ringe, D.,Agar, N.Y.R.,Greenblatt, D.J.,Ondrechen, M.J.,Chen, Y.,Yerbury, J.J.,Manetsch, R.,Hasnain, S.S.,Brown Jr., R.H.,Agar, J.N.; Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.; Plos Biol., 22:e3002462-e3002462, 2024; PubMed: 38289969; DOI: 10.1371/journal.pbio.3002462

Experimental method

X-RAY DIFFRACTION (1.665 Å)