8GSQ

Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.

Summary for 8GSQ

Entry DOI	10.2210/pdb8gsq/pdb
Descriptor	Superoxide dismutase [Cu-Zn], ZINC ION, GLYCEROL, ... (8 entities in total)
Functional Keywords	superoxide dismutase, als, antipsychotic, oxidation, oxidoreductase-inhibitor complex, oxidoreductase
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	160801.82
Authors	Aouti, S.,Padmanabhan, B. (deposition date: 2022-09-06, release date: 2023-06-14, Last modification date: 2023-09-20)
Primary citation	Aouti, S.,Padavattan, S.,Padmanabhan, B. Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis. Acta Crystallogr D Struct Biol, 79:531-544, 2023 Cited by PubMed: 37204819 DOI: 10.1107/S2059798323003649 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation