8GSQ
Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.
Summary for 8GSQ
Entry DOI | 10.2210/pdb8gsq/pdb |
Descriptor | Superoxide dismutase [Cu-Zn], ZINC ION, GLYCEROL, ... (8 entities in total) |
Functional Keywords | superoxide dismutase, als, antipsychotic, oxidation, oxidoreductase-inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 10 |
Total formula weight | 160801.82 |
Authors | Aouti, S.,Padmanabhan, B. (deposition date: 2022-09-06, release date: 2023-06-14, Last modification date: 2023-09-20) |
Primary citation | Aouti, S.,Padavattan, S.,Padmanabhan, B. Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis. Acta Crystallogr D Struct Biol, 79:531-544, 2023 Cited by PubMed: 37204819DOI: 10.1107/S2059798323003649 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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