7LZ4
 
 | | Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed | | Authors: | Del Rio, J, Wu, J, Taylor, S.S. | | Deposit date: | 2021-03-08 | | Release date: | 2021-05-26 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (4.155 Å) | | Cite: | Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
6FLO
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution | | Descriptor: | GLYCEROL, INOSINE, Protein kinase A regulatory subunit | | Authors: | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | Deposit date: | 2018-01-26 | | Release date: | 2019-08-14 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.13868666 Å) | | Cite: | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
|
|
1VP6
 | | M.loti ion channel cylic nucleotide binding domain | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, BROMIDE ION, Cyclic-nucleotide binding domain of mesorhizobium loti CNG potassium channel | | Authors: | Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H. | | Deposit date: | 2004-10-14 | | Release date: | 2004-10-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.
Cell(Cambridge,Mass.), 119, 2004
|
|
1Q43
 | | HCN2I 443-640 in the presence of cAMP, selenomethionine derivative | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | | Deposit date: | 2003-08-01 | | Release date: | 2003-09-09 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for modulation and agonist specificity of HCN pacemaker channels
Nature, 425, 2003
|
|
3FFQ
 | | HCN2I 443-640 apo-state | | Descriptor: | BROMIDE ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Olivier, N.B. | | Deposit date: | 2008-12-04 | | Release date: | 2009-06-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mapping the structure and conformational movements of proteins with transition metal ion FRET.
Nat.Methods, 6, 2009
|
|
1Q3E
 | | HCN2J 443-645 in the presence of cGMP | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | | Deposit date: | 2003-07-29 | | Release date: | 2003-09-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for modulation and agonist specificity of HCN pacemaker channels
Nature, 425, 2003
|
|
6SYG
 | |
1CX4
 | |
4QXK
 | | Joint X-ray/neutron structure of PKGIbeta in complex with cGMP | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION, cGMP-dependent protein kinase 1 | | Authors: | Kim, C, Gerlits, O, Kovalevsky, A, Huang, G.Y. | | Deposit date: | 2014-07-21 | | Release date: | 2014-11-12 | | Last modified: | 2024-02-28 | | Method: | NEUTRON DIFFRACTION (2.2 Å), X-RAY DIFFRACTION | | Cite: | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.
Biochemistry, 53, 2014
|
|
6NP6
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | Descriptor: | Crp/Fnr family transcriptional regulator, GLYCEROL | | Authors: | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P. | | Deposit date: | 2019-01-17 | | Release date: | 2019-06-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
2D93
 | |
5T3N
 | | Sp-2Cl-cAMPS bound to PKAR CBD2 | | Descriptor: | (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit | | Authors: | Littler, D.R, Gilson, P. | | Deposit date: | 2016-08-26 | | Release date: | 2016-10-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
|
|
4MUV
 | | M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated potassium channel mll3241, SODIUM ION | | Authors: | Fonseca, F, Pessoa, J, Morais-Cabral, J.H. | | Deposit date: | 2013-09-23 | | Release date: | 2014-06-25 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Determinants of ligand selectivity in a cyclic nucleotide-regulated potassium channel.
J.Gen.Physiol., 144, 2014
|
|
5BV6
 | | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP | | Descriptor: | ACETATE ION, CALCIUM ION, GUANOSINE-3',5'-MONOPHOSPHATE, ... | | Authors: | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | | Deposit date: | 2015-06-04 | | Release date: | 2016-01-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
|
|
1RL3
 | | Crystal structure of cAMP-free R1a subunit of PKA | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory chain | | Authors: | Wu, J, Brown, S, Xuong, N.-H, Taylor, S.S. | | Deposit date: | 2003-11-24 | | Release date: | 2004-07-06 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
Structure, 12, 2004
|
|
4Z07
 | | Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ... | | Authors: | Kim, J.J, Reger, A.S, Arold, S.T, Kim, C. | | Deposit date: | 2015-03-25 | | Release date: | 2016-04-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.
Structure, 24, 2016
|
|
1RGS
 | | REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP DEPENDENT PROTEIN KINASE | | Authors: | Su, Y, Dostmann, W.R.G, Herberg, F.W, Durick, K, Xuong, N.-H, Ten Eyck, L, Taylor, S.S, Varughese, K.I. | | Deposit date: | 1995-06-21 | | Release date: | 1996-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science, 269, 1995
|
|
5C6C
 | | PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cAMP | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CADMIUM ION, ... | | Authors: | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | | Deposit date: | 2015-06-22 | | Release date: | 2016-01-20 | | Last modified: | 2025-05-14 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
|
|
1U12
 | | M. loti cyclic nucleotide binding domain mutant | | Descriptor: | IODIDE ION, POTASSIUM ION, SULFATE ION, ... | | Authors: | Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H. | | Deposit date: | 2004-07-14 | | Release date: | 2004-11-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel
Cell(Cambridge,Mass.), 119, 2004
|
|
5C8W
 | | PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, MALONIC ACID, SODIUM ION, ... | | Authors: | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | | Deposit date: | 2015-06-26 | | Release date: | 2016-01-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
|
|
2PQQ
 | | Structural Genomics, the crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2) | | Descriptor: | FORMIC ACID, Putative transcriptional regulator | | Authors: | Tan, K, Xu, X, Zheng, H, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-05-02 | | Release date: | 2007-06-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2)
To be Published
|
|
2Q0A
 | | Structure and rearrangements in the carboxy-terminal region of SpIH channels | | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Flynn, G.E, Black, K.D, Islas, L.D, Sankaran, B, Zagotta, W.N. | | Deposit date: | 2007-05-21 | | Release date: | 2007-06-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Structure, 15, 2007
|
|
5V30
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | Descriptor: | GLYCEROL, SULFATE ION, Transcriptional regulator | | Authors: | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P. | | Deposit date: | 2017-03-06 | | Release date: | 2018-06-13 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
2KXL
 | |
5H5O
 | |
