5T3N
Sp-2Cl-cAMPS bound to PKAR CBD2
Summary for 5T3N
Entry DOI | 10.2210/pdb5t3n/pdb |
Related | 5K8S 5KBF |
Descriptor | cAMP-dependent protein kinase regulatory subunit, IODIDE ION, (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, ... (4 entities in total) |
Functional Keywords | protein kinase a, pkar, plasmodium, camp, cbd, cnb, cyclic nucleotide, cyclic adenosine monophosphate, transferase |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 2 |
Total formula weight | 38416.45 |
Authors | Littler, D.R.,Gilson, P. (deposition date: 2016-08-26, release date: 2016-10-12, Last modification date: 2023-10-04) |
Primary citation | Littler, D.R.,Bullen, H.E.,Harvey, K.L.,Beddoe, T.,Crabb, B.S.,Rossjohn, J.,Gilson, P.R. Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit. J. Biol. Chem., 291:25375-25386, 2016 Cited by PubMed: 27738107DOI: 10.1074/jbc.M116.750174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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