5T3N

Sp-2Cl-cAMPS bound to PKAR CBD2

Summary for 5T3N

• Entry DOI: 10.2210/pdb5t3n/pdb
• Related: 5K8S 5KBF
• Descriptor: cAMP-dependent protein kinase regulatory subunit, IODIDE ION, (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, ... (4 entities in total)
• Functional Keywords: protein kinase a, pkar, plasmodium, camp, cbd, cnb, cyclic nucleotide, cyclic adenosine monophosphate, transferase
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 2
• Total formula weight: 38416.45

Authors

Littler, D.R.,Gilson, P. (deposition date: 2016-08-26, release date: 2016-10-12, Last modification date: 2023-10-04)

• Primary citation: Littler, D.R.,Bullen, H.E.,Harvey, K.L.,Beddoe, T.,Crabb, B.S.,Rossjohn, J.,Gilson, P.R.; Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.; J. Biol. Chem., 291:25375-25386, 2016; PubMed: 27738107; DOI: 10.1074/jbc.M116.750174

Experimental method

X-RAY DIFFRACTION (2.4 Å)