Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 22 results

4ZX2
DownloadVisualize
BU of 4zx2 by Molmil
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Descriptor: (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E.
Deposit date:2015-05-19
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
3H63
DownloadVisualize
BU of 3h63 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Descriptor: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
3H62
DownloadVisualize
BU of 3h62 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with cantharidic acid
Descriptor: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
3H61
DownloadVisualize
BU of 3h61 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms originally soaked with norcantharidin (which is present in the structure in the hydrolyzed form)
Descriptor: (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
3H68
DownloadVisualize
BU of 3h68 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Descriptor: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, Serine/threonine-protein phosphatase 5, ZINC ION
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
1S95
DownloadVisualize
BU of 1s95 by Molmil
Structure of serine/threonine protein phosphatase 5
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Swingle, M.R, Honkanen, R.E, Ciszak, E.M.
Deposit date:2004-02-03
Release date:2004-08-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.
J.Biol.Chem., 279, 2004
3H67
DownloadVisualize
BU of 3h67 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms complexed with cantharidic acid
Descriptor: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, Serine/threonine-protein phosphatase 5, ZINC ION
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
5WG8
DownloadVisualize
BU of 5wg8 by Molmil
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
Descriptor: (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A.
Deposit date:2017-07-13
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18, 2019
3H64
DownloadVisualize
BU of 3h64 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with endothall
Descriptor: (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
5UI1
DownloadVisualize
BU of 5ui1 by Molmil
Crystal Structure of Human Protein Phosphatase 5C (PP5C) in complex with a triazole inhibitor
Descriptor: 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Banerjee, S, Honkanen, R.E.
Deposit date:2017-01-12
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure Human PP5C in Complex with an Inhibitor
To Be Published
4ZVZ
DownloadVisualize
BU of 4zvz by Molmil
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Descriptor: (1R,2S,3R,4S,5S)-5-(propoxymethyl)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ...
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E.
Deposit date:2015-05-18
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
3H60
DownloadVisualize
BU of 3h60 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Mn2+ atoms
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 5
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
3H69
DownloadVisualize
BU of 3h69 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms complexed with endothall
Descriptor: (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, Serine/threonine-protein phosphatase 5, ZINC ION
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
5HPE
DownloadVisualize
BU of 5hpe by Molmil
Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide
Descriptor: COBALT HEXAMMINE(III), MANGANESE (II) ION, Serine/threonine-protein phosphatase 5,Hsp90 co-chaperone Cdc37
Authors:Oberoi, J, Mariotti, L, Vaughan, C.
Deposit date:2016-01-20
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural and functional basis of protein phosphatase 5 substrate specificity.
Proc.Natl.Acad.Sci.USA, 113, 2016
1A17
DownloadVisualize
BU of 1a17 by Molmil
TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
Descriptor: SERINE/THREONINE PROTEIN PHOSPHATASE 5, SULFATE ION
Authors:Das, A.K, Cohen, P.T.W, Barford, D.
Deposit date:1997-12-23
Release date:1998-04-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.
EMBO J., 17, 1998
3H66
DownloadVisualize
BU of 3h66 by Molmil
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms
Descriptor: Serine/threonine-protein phosphatase 5, ZINC ION
Authors:Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E.
Deposit date:2009-04-23
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
J.Med.Chem., 52, 2009
1WAO
DownloadVisualize
BU of 1wao by Molmil
PP5 structure
Descriptor: MANGANESE (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE 5
Authors:Barford, D.
Deposit date:2004-10-27
Release date:2005-02-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Basis for Tpr Domain-Mediated Regulation of Protein Phosphatase 5
Embo J., 24, 2005
8GAE
DownloadVisualize
BU of 8gae by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-02-22
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
8GFT
DownloadVisualize
BU of 8gft by Molmil
Hsp90 provides platform for CRaf dephosphorylation by PP5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ...
Authors:Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A.
Deposit date:2023-03-08
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Hsp90 provides a platform for kinase dephosphorylation by PP5.
Nat Commun, 14, 2023
7ZR5
DownloadVisualize
BU of 7zr5 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-14
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
7ZR6
DownloadVisualize
BU of 7zr6 by Molmil
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ...
Authors:Oberoi, J, Pearl, L.H.
Deposit date:2022-05-03
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Nat Commun, 13, 2022
2BUG
DownloadVisualize
BU of 2bug by Molmil
Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide
Descriptor: HSP90, SERINE/THREONINE PROTEIN PHOSPHATASE 5
Authors:Cliff, M.J, Harris, R, Barford, D, Ladbury, J.E, Williams, M.A.
Deposit date:2005-06-13
Release date:2006-03-16
Last modified:2020-01-15
Method:SOLUTION NMR
Cite:Conformational Diversity in the Tpr Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90.
Structure, 14, 2006

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon