3W9I
| Structural basis for the inhibition of bacterial multidrug exporters | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB | Authors: | Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A. | Deposit date: | 2013-04-04 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural basis for the inhibition of bacterial multidrug exporters Nature, 500, 2013
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6IIA
| MexB in complex with LMNG | Descriptor: | Lauryl Maltose Neopentyl Glycol, Multidrug resistance protein MexB | Authors: | Nakashima, R, Sakurai, K, Nakao, K. | Deposit date: | 2018-10-04 | Release date: | 2019-03-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds. Sci Rep, 9, 2019
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2V50
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3W9J
| Structural basis for the inhibition of bacterial multidrug exporters | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Multidrug resistance protein MexB, [{2-[({[(3R)-1-{8-[(4-tert-butyl-1,3-thiazol-2-yl)carbamoyl]-4-oxo-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-4H-pyrido[1,2-a]pyrimidin-2-yl}piperidin-3-yl]oxy}carbonyl)amino]ethyl}(dimethyl)ammonio]acetate | Authors: | Sakurai, K, Nakashima, R, Hayashi, K, Yamaguchi, A. | Deposit date: | 2013-04-04 | Release date: | 2013-07-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural basis for the inhibition of bacterial multidrug exporters Nature, 500, 2013
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6TA6
| MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs | Descriptor: | Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM | Authors: | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | Deposit date: | 2019-10-29 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
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6TA5
| OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs | Descriptor: | Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM | Authors: | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | Deposit date: | 2019-10-29 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
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6IOK
| Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | Descriptor: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | Authors: | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2019-04-17 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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6IOL
| Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | Descriptor: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | Authors: | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | Deposit date: | 2018-10-30 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
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6T7S
| MexB structure solved by cryo-EM in nanodisc in absence of its protein partners | Descriptor: | Efflux pump membrane transporter | Authors: | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | Deposit date: | 2019-10-23 | Release date: | 2020-09-16 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
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