2B5I
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![BU of 2b5i by Molmil](/molmil-images/mine/2b5i) | cytokine receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common gamma chain, ... | Authors: | Wang, X, Rickert, M, Garcia, K.C. | Deposit date: | 2005-09-28 | Release date: | 2005-11-29 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science, 310, 2005
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5M5E
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![BU of 5m5e by Molmil](/molmil-images/mine/5m5e) | Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Klein, C, Freimoser-Grundschober, A, Waldhauer, I, Stihle, M, Birk, M, Benz, J. | Deposit date: | 2016-10-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology, 6, 2017
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4GS7
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![BU of 4gs7 by Molmil](/molmil-images/mine/4gs7) | Structure of the Interleukin-15 quaternary complex | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ring, A.M, Ozkan, E, Feng, D, Garcia, K.C. | Deposit date: | 2012-08-27 | Release date: | 2012-11-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat.Immunol., 13, 2012
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7S2R
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![BU of 7s2r by Molmil](/molmil-images/mine/7s2r) | nanobody bound to IL-2Rg | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | Authors: | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | Deposit date: | 2021-09-03 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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8ENT
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![BU of 8ent by Molmil](/molmil-images/mine/8ent) | Interleukin-21 signaling complex with IL-21R and IL-2Rg | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-09-30 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | A structural blueprint for interleukin-21 signal modulation. Cell Rep, 42, 2023
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3BPL
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![BU of 3bpl by Molmil](/molmil-images/mine/3bpl) | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Garcia, K.C. | Deposit date: | 2007-12-18 | Release date: | 2008-02-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Cell(Cambridge,Mass.), 132, 2008
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2ERJ
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![BU of 2erj by Molmil](/molmil-images/mine/2erj) | Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Debler, E.W, Stauber, D.J, Wilson, I.A. | Deposit date: | 2005-10-25 | Release date: | 2006-02-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor. Proc.Natl.Acad.Sci.Usa, 103, 2006
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6OEL
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![BU of 6oel by Molmil](/molmil-images/mine/6oel) | Engineered Fab bound to IL-4 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... | Authors: | Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. | Deposit date: | 2019-03-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A strategy for the selection of monovalent antibodies that span protein dimer interfaces. J.Biol.Chem., 294, 2019
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3QB7
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![BU of 3qb7 by Molmil](/molmil-images/mine/3qb7) | Interleukin-4 mutant RGA bound to cytokine receptor common gamma | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | Authors: | Bates, D.L, Junttila, I.S, Creusot, R.J, Moraga, I, Lupardus, P, Fathman, C.G, Paul, W.E, Garcia, K.C. | Deposit date: | 2011-01-12 | Release date: | 2012-04-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.245 Å) | Cite: | Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nat.Chem.Biol., 8, 2012
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8EPA
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![BU of 8epa by Molmil](/molmil-images/mine/8epa) | |
3QAZ
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![BU of 3qaz by Molmil](/molmil-images/mine/3qaz) | IL-2 mutant D10 ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ... | Authors: | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C. | Deposit date: | 2011-01-12 | Release date: | 2012-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.802 Å) | Cite: | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
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