8EPA

Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies

Summary for 8EPA

• Entry DOI: 10.2210/pdb8epa/pdb
• EMDB information: 28523
• Descriptor: Cytokine receptor common subunit gamma, REGN7257 Fab heavy chain, REGN7257 Fab light chain, ... (6 entities in total)
• Functional Keywords: interleukin signaling, lymphocyte maturation, blocking antibody, immunoglobulin, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 125760.90

Authors

Franklin, M.C.,Romero Hernandez, A. (deposition date: 2022-10-05, release date: 2023-01-25)

• Primary citation: Le Floc'h, A.,Nagashima, K.,Birchard, D.,Scott, G.,Ben, L.H.,Ajithdoss, D.,Gayvert, K.,Romero Hernandez, A.,Herbin, O.,Tay, A.,Farrales, P.,Korgaonkar, C.K.,Pan, H.,Shah, S.,Kamat, V.,Chatterjee, I.,Popke, J.,Oyejide, A.,Lim, W.K.,Kim, J.H.,Huang, T.,Franklin, M.,Olson, W.,Norton, T.,Perlee, L.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.A.,Orengo, J.M.; Blocking common gamma chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.; Sci Transl Med, 15:eabo0205-eabo0205, 2023; PubMed: 36630481; DOI: 10.1126/scitranslmed.abo0205

Experimental method

ELECTRON MICROSCOPY (3.4 Å)