8EPA

Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (I)	Cytokine receptor common subunit gamma	polymer	268	31617.1	1	UniProt (P31785) Pfam (PF22012) Pfam (PF21605)	Homo sapiens (human)	Interleukin-2 receptor subunit gamma,IL-2 receptor subunit gamma,IL-2R subunit gamma,IL-2RG,gammaC,p64
2	B (H)	REGN7257 Fab heavy chain	polymer	220	23607.5	1		Mus musculus
3	C (L)	REGN7257 Fab light chain	polymer	214	23541.1	1		Mus musculus
4	D (A)	REGN9432 Fab heavy chain	polymer	221	23323.0	1		Mus musculus
5	E (B)	REGN9432 Fab light chain	polymer	214	23247.8	1		Mus musculus
6	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)

Sequence modifications

I: 1 - 240 (UniProt: P31785)

PDB	External Database	Details
Glu 241	-	expression tag
Gln 242	-	expression tag
Lys 243	-	expression tag
Leu 244	-	expression tag
Ile 245	-	expression tag
Ser 246	-	expression tag
Glu 247	-	expression tag
Glu 248	-	expression tag
Asp 249	-	expression tag
Leu 250	-	expression tag
Gly 251	-	expression tag
Gly 252	-	expression tag
Glu 253	-	expression tag
Gln 254	-	expression tag
Lys 255	-	expression tag
Leu 256	-	expression tag
Ile 257	-	expression tag
Ser 258	-	expression tag
Glu 259	-	expression tag
Glu 260	-	expression tag
Asp 261	-	expression tag
Leu 262	-	expression tag
His 263	-	expression tag
His 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	125336.5
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	125760.9

*Water molecules are not included.