3QB7

Interleukin-4 mutant RGA bound to cytokine receptor common gamma

Summary for 3QB7

Entry DOI	10.2210/pdb3qb7/pdb
Descriptor	Interleukin 4, Cytokine receptor common subunit gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	cytokine signaling, il-4ralpha, cytokine-cytokine receptor complex, cytokine/cytokine receptor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	80630.74
Authors	Bates, D.L.,Junttila, I.S.,Creusot, R.J.,Moraga, I.,Lupardus, P.,Fathman, C.G.,Paul, W.E.,Garcia, K.C. (deposition date: 2011-01-12, release date: 2012-04-25, Last modification date: 2023-12-27)
Primary citation	Junttila, I.S.,Creusot, R.J.,Moraga, I.,Bates, D.L.,Wong, M.T.,Alonso, M.N.,Suhoski, M.M.,Lupardus, P.,Meier-Schellersheim, M.,Engleman, E.G.,Utz, P.J.,Fathman, C.G.,Paul, W.E.,Garcia, K.C. Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nat.Chem.Biol., 8:990-998, 2012 Cited by PubMed: 23103943 DOI: 10.1038/nchembio.1096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.245 Å)

Structure validation