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3QB7

Interleukin-4 mutant RGA bound to cytokine receptor common gamma

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005136molecular_functioninterleukin-4 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0008203biological_processcholesterol metabolic process
A0008284biological_processpositive regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010633biological_processnegative regulation of epithelial cell migration
A0016239biological_processpositive regulation of macroautophagy
A0030183biological_processB cell differentiation
A0030335biological_processpositive regulation of cell migration
A0030890biological_processpositive regulation of B cell proliferation
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032733biological_processpositive regulation of interleukin-10 production
A0032736biological_processpositive regulation of interleukin-13 production
A0035771biological_processinterleukin-4-mediated signaling pathway
A0042092biological_processtype 2 immune response
A0042102biological_processpositive regulation of T cell proliferation
A0042110biological_processT cell activation
A0042113biological_processB cell activation
A0042116biological_processmacrophage activation
A0043011biological_processmyeloid dendritic cell differentiation
A0043066biological_processnegative regulation of apoptotic process
A0045191biological_processregulation of isotype switching
A0045321biological_processleukocyte activation
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045582biological_processpositive regulation of T cell differentiation
A0045671biological_processnegative regulation of osteoclast differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0048295biological_processpositive regulation of isotype switching to IgE isotypes
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050728biological_processnegative regulation of inflammatory response
A0050776biological_processregulation of immune response
A0051239biological_processregulation of multicellular organismal process
A0080090biological_processregulation of primary metabolic process
A0097028biological_processdendritic cell differentiation
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0150076biological_processneuroinflammatory response
A0150079biological_processnegative regulation of neuroinflammatory response
A1900223biological_processpositive regulation of amyloid-beta clearance
A1901857biological_processpositive regulation of cellular respiration
A1903660biological_processnegative regulation of complement-dependent cytotoxicity
A1903845biological_processnegative regulation of cellular response to transforming growth factor beta stimulus
A2000352biological_processnegative regulation of endothelial cell apoptotic process
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005136molecular_functioninterleukin-4 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006955biological_processimmune response
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008083molecular_functiongrowth factor activity
B0008203biological_processcholesterol metabolic process
B0008284biological_processpositive regulation of cell population proliferation
B0010628biological_processpositive regulation of gene expression
B0010633biological_processnegative regulation of epithelial cell migration
B0016239biological_processpositive regulation of macroautophagy
B0030183biological_processB cell differentiation
B0030335biological_processpositive regulation of cell migration
B0030890biological_processpositive regulation of B cell proliferation
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032733biological_processpositive regulation of interleukin-10 production
B0032736biological_processpositive regulation of interleukin-13 production
B0035771biological_processinterleukin-4-mediated signaling pathway
B0042092biological_processtype 2 immune response
B0042102biological_processpositive regulation of T cell proliferation
B0042110biological_processT cell activation
B0042113biological_processB cell activation
B0042116biological_processmacrophage activation
B0043011biological_processmyeloid dendritic cell differentiation
B0043066biological_processnegative regulation of apoptotic process
B0045191biological_processregulation of isotype switching
B0045321biological_processleukocyte activation
B0045348biological_processpositive regulation of MHC class II biosynthetic process
B0045582biological_processpositive regulation of T cell differentiation
B0045671biological_processnegative regulation of osteoclast differentiation
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048295biological_processpositive regulation of isotype switching to IgE isotypes
B0048304biological_processpositive regulation of isotype switching to IgG isotypes
B0050728biological_processnegative regulation of inflammatory response
B0050776biological_processregulation of immune response
B0051239biological_processregulation of multicellular organismal process
B0080090biological_processregulation of primary metabolic process
B0097028biological_processdendritic cell differentiation
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0150076biological_processneuroinflammatory response
B0150079biological_processnegative regulation of neuroinflammatory response
B1900223biological_processpositive regulation of amyloid-beta clearance
B1901857biological_processpositive regulation of cellular respiration
B1903660biological_processnegative regulation of complement-dependent cytotoxicity
B1903845biological_processnegative regulation of cellular response to transforming growth factor beta stimulus
B2000352biological_processnegative regulation of endothelial cell apoptotic process
B2000553biological_processpositive regulation of T-helper 2 cell cytokine production
B2001171biological_processpositive regulation of ATP biosynthetic process
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0004896molecular_functioncytokine receptor activity
D0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00838
Number of Residues26
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LqEIIktlnsLTeqktl..CteltVtDI
ChainResidueDetails
ALEU7-ILE32

site_idPS01355
Number of Residues34
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VdgqkrytfrVRsrfnplcgsaqh........WSeWShpihW
ChainResidueDetails
CVAL191-TRP224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1993171
ChainResidueDetails
AASN38
BASN38
CASN137
DASN49
DASN62
DASN137

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CGLN53
CASN227
DGLN53
DASN227

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PDB entries from 2025-06-18

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