3QB7

Interleukin-4 mutant RGA bound to cytokine receptor common gamma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin 4	polymer	132	15264.6	2	UniProt (D4HNR6) Pfam (PF00727) UniProt (by SIFTS) (P05112)	Homo sapiens (human)
2	C, D (C, D)	Cytokine receptor common subunit gamma	polymer	203	24309.1	2	UniProt (P31785) Pfam (PF22012) Pfam (PF21605)	Homo sapiens (human)	Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, p64
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	I, J (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 1 - 129 (UniProt: D4HNR6)

PDB	External Database	Details
Ala -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Arg 117	Lys 141	engineered mutation
Val 118	Thr 142	engineered mutation
Gln 121	Arg 145	engineered mutation
Ser 122	Glu 146	engineered mutation
Trp 124	Tyr 148	engineered mutation
Phe 125	Ser 149	engineered mutation
Gly 128	Ser 152	engineered mutation
Ala 129	Ser 153	engineered mutation

C, D: 33 - 232 (UniProt: P31785)

PDB	External Database	Details
Ala 30	-	expression tag
Asp 31	-	expression tag
Pro 32	-	expression tag
Gln 53	Asn 75	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79147.4
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	4
	Total formula weight	634.5
All*	Total formula weight	80630.7

*Water molecules are not included.