8Q68
 
 | | Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143 | | Descriptor: | Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide | | Authors: | Ciesielski, F, Spieser, S.A.H, Marchand, A, Gwaltney, S.L. | | Deposit date: | 2023-08-11 | | Release date: | 2023-10-04 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Mol.Cancer Ther., 23, 2024
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6IM5
 | | YAP-binding domain of human TEAD1 | | Descriptor: | PHOSPHATE ION, Transcriptional enhancer factor TEF-1 | | Authors: | Mo, Y, Lee, H.S, Kim, S.J, Ku, B. | | Deposit date: | 2018-10-22 | | Release date: | 2019-02-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.701 Å) | | Cite: | Crystal Structure of the YAP-binding Domain of Human TEAD1
Bull.Korean Chem.Soc., 40, 2019
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4Z8E
 | | TEAD DBD mutant -deltaL1 | | Descriptor: | Transcriptional enhancer factor TEF-1 | | Authors: | Lee, D.-S, Albarado, D.C, Vonrhein, C, Raman, C.S, Veeraraghavan, S. | | Deposit date: | 2015-04-08 | | Release date: | 2016-04-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.092 Å) | | Cite: | A Potential Structural Switch for Regulating DNA-Binding by TEAD Transcription Factors.
J.Mol.Biol., 428, 2016
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7ZJP
 | | Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 | | Descriptor: | 2-methyl-4-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]indole-7-carboxylic acid, SULFATE ION, Transcriptional enhancer factor TEF-1 | | Authors: | Freire, F, Heinrich, T, Petersson, C, Schneider, R, Garg, S, Schwarz, D, Gunera, J, Seshire, A, Koetzner, L, Schlesiger, S, Musil, D, Schilke, H, Doerfel, B, Diehl, P, Boepple, P, Lemos, A.R, Sousa, P.M.F, Freire, F, Bandeiras, T.M, Carswell, E, Pearson, N, Sirohi, S, Hooker, M, Trivier, E, Broome, R, Balsiger, A, Crowden, A, Dillon, C, Wienke, D. | | Deposit date: | 2022-04-11 | | Release date: | 2022-07-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 .
J.Med.Chem., 65, 2022
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4RE1
 | | Crystal structure of human TEAD1 and disulfide-engineered YAP | | Descriptor: | CHLORIDE ION, Transcriptional enhancer factor TEF-1, Yorkie homolog | | Authors: | Xu, Z, Zhou, Z. | | Deposit date: | 2014-09-21 | | Release date: | 2014-11-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
Faseb J., 29, 2015
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6HIL
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3KYS
 | | Crystal structure of human YAP and TEAD complex | | Descriptor: | 65 kDa Yes-associated protein, Transcriptional enhancer factor TEF-1 | | Authors: | Li, Z, Zhao, B, Wang, P, Chen, F, Dong, Z, Yang, H, Guan, K.L, Xu, Y. | | Deposit date: | 2009-12-07 | | Release date: | 2010-02-23 | | Last modified: | 2020-10-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural insights into the YAP and TEAD complex
Genes Dev., 24, 2010
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5NNX
 | | TEAD1 bound to DNA | | Descriptor: | DNA, Transcriptional enhancer factor TEF-1 | | Authors: | Morgunova, E, Jolma, A, Yin, Y, Popov, A, Taipale, J. | | Deposit date: | 2017-04-10 | | Release date: | 2017-04-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | TEAD1 bound to DNA
To Be Published
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7CMM
 | | Crystal structure of TEAD1-YBD in complex with K-975 | | Descriptor: | N-[3-(4-chloranylphenoxy)-4-methyl-phenyl]propanamide, Transcriptional enhancer factor TEF-1 | | Authors: | Tsuji, Y, Suzuki, M, Yasunaga, M, Hamguchi, K, Saito, J. | | Deposit date: | 2020-07-28 | | Release date: | 2021-02-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.
Am J Cancer Res, 10, 2020
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2HZD
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