7CMM

Crystal structure of TEAD1-YBD in complex with K-975

Summary for 7CMM

• Entry DOI: 10.2210/pdb7cmm/pdb
• Descriptor: Transcriptional enhancer factor TEF-1, N-[3-(4-chloranylphenoxy)-4-methyl-phenyl]propanamide (3 entities in total)
• Functional Keywords: transcriptional enhancer factor tef-1, tead, tead1, yap binding domain, ybd, inhibitor, covalent binder, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 107439.68

Authors

Tsuji, Y.,Suzuki, M.,Yasunaga, M.,Hamguchi, K.,Saito, J. (deposition date: 2020-07-28, release date: 2021-02-03, Last modification date: 2023-11-29)

• Primary citation: Kaneda, A.,Seike, T.,Danjo, T.,Nakajima, T.,Otsubo, N.,Yamaguchi, D.,Tsuji, Y.,Hamaguchi, K.,Yasunaga, M.,Nishiya, Y.,Suzuki, M.,Saito, J.I.,Yatsunami, R.,Nakamura, S.,Sekido, Y.,Mori, K.; The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.; Am J Cancer Res, 10:4399-4415, 2020; PubMed: 33415007

Experimental method

X-RAY DIFFRACTION (3.5 Å)