Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 61 results

6YYR
DownloadVisualize
BU of 6yyr by Molmil
Structure of Cathepsin S in complex with Compound 20b
Descriptor: (2~{R})-~{N}-(2-azanylideneethyl)-2-[2-(3-methyl-1,2-oxazol-5-yl)ethanoylamino]-3-(4-pyridin-2-ylpiperazin-1-yl)sulfonyl-propanamide, 1,2-ETHANEDIOL, CITRATE ANION, ...
Authors:Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q.
Deposit date:2020-05-05
Release date:2021-05-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors.
J.Med.Chem., 63, 2020
3OVX
DownloadVisualize
BU of 3ovx by Molmil
Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead
Descriptor: 2-chloro-N-[(1S)-1-formylpropyl]-3-(trifluoromethyl)benzamide, Cathepsin S, DIMETHYL SULFOXIDE
Authors:Fradera, X, van Zeeland, M, Uitdehaag, J.C.M.
Deposit date:2010-09-17
Release date:2010-12-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
6YYO
DownloadVisualize
BU of 6yyo by Molmil
Structure of Cathepsin S in complex with Compound 1
Descriptor: 1,2-ETHANEDIOL, 6-(4-methylsulfonylpiperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, CITRATE ANION, ...
Authors:Wagener, M, Schade, M, Merla, B, Hars, U, Kueckelhaus, S.Q.
Deposit date:2020-05-05
Release date:2021-05-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors.
J.Med.Chem., 63, 2020
2H7J
DownloadVisualize
BU of 2h7j by Molmil
Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.
Descriptor: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Cathepsin S, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE
Authors:Patterson, A.W, Wood, W.J, Hornsby, M, Lesley, S, Spraggon, G, Ellman, J.A.
Deposit date:2006-06-02
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
J.Med.Chem., 49, 2006
2HHN
DownloadVisualize
BU of 2hhn by Molmil
Cathepsin S in complex with non covalent arylaminoethyl amide.
Descriptor: Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, SULFATE ION
Authors:Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K.
Deposit date:2006-06-28
Release date:2007-05-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg.Med.Chem.Lett., 16, 2006
8RND
DownloadVisualize
BU of 8rnd by Molmil
Cathepsin S in complex with NNPI-C10 inhibitor
Descriptor: 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ...
Authors:Petruzzella, A, Lau, K, Pojer, F, Oricchio, E.
Deposit date:2024-01-09
Release date:2024-06-05
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Nat.Chem.Biol., 2024
4P6G
DownloadVisualize
BU of 4p6g by Molmil
Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.
Descriptor: (3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl methylcarbamate, Cathepsin S
Authors:Wang, Y, Jadhav, P.K.
Deposit date:2014-03-24
Release date:2014-10-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Acs Med.Chem.Lett., 5, 2014
2FRQ
DownloadVisualize
BU of 2frq by Molmil
Human Cathepsin S with Inhibitor CRA-26871
Descriptor: N-[4-(AMINOMETHYL)-1,1-DIOXIDOTETRAHYDRO-2H-THIOPYRAN-4-YL]-3-(1-METHYLCYCLOPENTYL)-N~2~-[(1E)-N-(PHENYLSULFONYL)ETHANIMIDOYL]-L-ALANINAMIDE, cathepsin S
Authors:Somoza, J.R.
Deposit date:2006-01-19
Release date:2006-07-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Human Cathepsin S with Inhibitor CRA-26871
To be Published
2OP3
DownloadVisualize
BU of 2op3 by Molmil
The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method
Descriptor: 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, Cathepsin S, ...
Authors:Spraggon, G, Inagaki, H, Tsuruoka, H, Hornsby, M, Lesley, S.A, Ellman, J.A.
Deposit date:2007-01-26
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode.
J.Med.Chem., 50, 2007
3N3G
DownloadVisualize
BU of 3n3g by Molmil
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Descriptor: (E)-1-(6-{4-[3-(4-methylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl}pyridin-2-yl)methanimine, 6-{4-[3-(4-methylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl}pyridine-2-carbonitrile, Cathepsin S, ...
Authors:Fradera, X, Uitdehaag, J.C.M, van Zeeland, M.
Deposit date:2010-05-20
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.
Bioorg.Med.Chem.Lett., 20, 2010
2FQ9
DownloadVisualize
BU of 2fq9 by Molmil
Cathepsin S with nitrile inhibitor
Descriptor: N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE, cathepsin S
Authors:Somoza, J.R.
Deposit date:2006-01-17
Release date:2006-03-21
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Cathepsin S with nitrile inhibitor
To be Published
2FT2
DownloadVisualize
BU of 2ft2 by Molmil
Human Cathepsin S with Inhibitor CRA-29728
Descriptor: N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE, cathepsin S
Authors:Somoza, J.R.
Deposit date:2006-01-23
Release date:2006-07-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human Cathepsin S with Inhibitor CRA-29728
To be Published
8PI3
DownloadVisualize
BU of 8pi3 by Molmil
Cathepsin S Y132D mutant in complex with NNPI-C10 inhibitor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CADMIUM ION, ...
Authors:Petruzzella, A, Lau, K, Pojer, F, Oricchio, E.
Deposit date:2023-06-21
Release date:2024-06-05
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Nat.Chem.Biol., 2024
5QC8
DownloadVisualize
BU of 5qc8 by Molmil
Crystal structure of human Cathepsin-S with bound ligand
Descriptor: Cathepsin S, N-benzyl-1-{3-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]phenyl}methanamine
Authors:Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2021-11-17
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of human Cathepsin-S with bound ligand
To be published
5QBV
DownloadVisualize
BU of 5qbv by Molmil
Crystal structure of human Cathepsin-S with bound ligand
Descriptor: Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzyl]benzamide
Authors:Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2021-11-17
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Bioorg.Med.Chem.Lett., 20, 2010
1NQC
DownloadVisualize
BU of 1nqc by Molmil
Crystal structures of Cathepsin S inhibitor complexes
Descriptor: Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE
Authors:Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L.
Deposit date:2003-01-21
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Specificity determinants of human cathepsin s revealed by crystal structures of complexes.
Biochemistry, 42, 2003
5QCC
DownloadVisualize
BU of 5qcc by Molmil
Crystal structure of human Cathepsin-S with bound ligand
Descriptor: Cathepsin S, tert-butyl 4-(2-{3-(4-chloro-3-iodophenyl)-1-[3-(morpholin-4-yl)propyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}-2-oxoethyl)piperidine-1-carboxylate
Authors:Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2021-11-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human Cathepsin-S with bound ligand
To be published
4P6E
DownloadVisualize
BU of 4p6e by Molmil
Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor
Descriptor: Cathepsin S, N-[(8R)-8-(benzoylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide, SULFATE ION
Authors:Wang, Y, Jadhav, P.K, Deng, G.G.
Deposit date:2014-03-24
Release date:2014-10-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Acs Med.Chem.Lett., 5, 2014
2HH5
DownloadVisualize
BU of 2hh5 by Molmil
Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide
Descriptor: CHLORIDE ION, Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, ...
Authors:Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S.
Deposit date:2006-06-27
Release date:2006-08-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.
Bioorg.Med.Chem.Lett., 16, 2006
2FRA
DownloadVisualize
BU of 2fra by Molmil
Human Cathepsin S with CRA-27934, a Nitrile Inhibitor
Descriptor: N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE, cathepsin S
Authors:Somoza, J.R.
Deposit date:2006-01-19
Release date:2006-07-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human Cathepsin S with CRA-27934, a Nitrile Inhibitor
To be Published
5QC0
DownloadVisualize
BU of 5qc0 by Molmil
Crystal structure of human Cathepsin-S with bound ligand
Descriptor: 2-(dimethylamino)-1-[4-(2-oxo-2-{3-[3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-propyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethyl)piperidin-1-yl]ethan-1-one, Cathepsin S
Authors:Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2021-11-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Cathepsin-S with bound ligand
To be published
1MS6
DownloadVisualize
BU of 1ms6 by Molmil
Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
Descriptor: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE
Authors:Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M.
Deposit date:2002-09-19
Release date:2003-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
J.Med.Chem., 45, 2002
5QC7
DownloadVisualize
BU of 5qc7 by Molmil
Crystal structure of human Cathepsin-S with bound ligand
Descriptor: 2-[1-(cyclohexylmethyl)piperidin-4-yl]-1-{3-[3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-propyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, Cathepsin S, DIMETHYL SULFOXIDE, ...
Authors:Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2021-11-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human Cathepsin-S with bound ligand
To be published
3N4C
DownloadVisualize
BU of 3n4c by Molmil
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Descriptor: (E)-1-(1-methyl-6-{4-[3-(4-methylpiperazin-1-yl)propoxy]-3-(trifluoromethyl)phenyl}-1H-imidazo[4,5-c]pyridin-4-yl)methanimine, Cathepsin S, DIMETHYL SULFOXIDE, ...
Authors:Fradera, X, Uitdehaag, J.C.M, van Zeeland, M.
Deposit date:2010-05-21
Release date:2011-04-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
2HXZ
DownloadVisualize
BU of 2hxz by Molmil
Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)
Descriptor: Cathepsin S, N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE, SULFATE ION
Authors:Patterson, A.W, Wood, W.J, Hornsby, M, Lesley, S, Spraggon, G, Ellman, J.A.
Deposit date:2006-08-04
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
J.Med.Chem., 49, 2006

 

123>

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon