5QC7
Crystal structure of human Cathepsin-S with bound ligand
Summary for 5QC7
Entry DOI | 10.2210/pdb5qc7/pdb |
Group deposition | Ligand binding to Cathepsin S (G_1002040) |
Descriptor | Cathepsin S, 2-[1-(cyclohexylmethyl)piperidin-4-yl]-1-{3-[3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-propyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, ETHANOL, ... (5 entities in total) |
Functional Keywords | d3r, cathepsin s, ligand docking, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 50689.25 |
Authors | Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-08-04, release date: 2017-12-20, Last modification date: 2024-11-06) |
Primary citation | Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. Crystal structure of human Cathepsin-S with bound ligand To be published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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