2F1G
Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide
Summary for 2F1G
Entry DOI | 10.2210/pdb2f1g/pdb |
Descriptor | Cathepsin S, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | cathepsin s, noncovalent, inhibition, 2-(benzooxazol-2-ylamino) acetamides, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P25774 |
Total number of polymer chains | 2 |
Total formula weight | 49747.97 |
Authors | Spraggon, G.,Hornsby, M.,Lesley, S.A.,Tully, D.C.,Harris, J.L.,Karenewsky, D.S.,Kulathila, R.,Clark, K. (deposition date: 2005-11-14, release date: 2006-04-04, Last modification date: 2011-07-13) |
Primary citation | Tully, D.C.,Liu, H.,Alper, P.B.,Chatterjee, A.K.,Epple, R.,Roberts, M.J.,Williams, J.A.,Nguyen, K.T.,Woodmansee, D.H.,Tumanut, C.,Li, J.,Spraggon, G.,Chang, J.,Tuntland, T.,Harris, J.L.,Karanewsky, D.S. Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorg.Med.Chem.Lett., 16:1975-1980, 2006 Cited by PubMed: 16446091DOI: 10.1016/j.bmcl.2005.12.095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report