8TQD
| NF-Kappa-B1 Bound with a Covalent Inhibitor | Descriptor: | 1-(2-bromo-4-chlorophenyl)-N-{(3S)-1-[(E)-iminomethyl]pyrrolidin-3-yl}methanesulfonamide, Nuclear factor NF-kappa-B p105 subunit | Authors: | Hilbert, B.J. | Deposit date: | 2023-08-07 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell, 187, 2024
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7LFC
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7RG5
| Importin alpha3 in complex with p50 NLS | Descriptor: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7LEQ
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7LET
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7RG4
| Importin alpha2 in complex with p50 NLS | Descriptor: | Importin subunit alpha-1, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | Authors: | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | Deposit date: | 2021-07-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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1SVC
| NFKB P50 HOMODIMER BOUND TO DNA | Descriptor: | DNA (5'-D(*AP*GP*AP*TP*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*CP*TP*A P*GP*A)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB)) | Authors: | Mueller, C.W, Harrison, S.C. | Deposit date: | 1995-11-27 | Release date: | 1996-06-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the NF-kappa B p50 homodimer bound to DNA. Nature, 373, 1995
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1NFI
| I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX | Descriptor: | I-KAPPA-B-ALPHA, NF-KAPPA-B P50, NF-KAPPA-B P65 | Authors: | Jacobs, M.D, Harrison, S.C. | Deposit date: | 1998-08-25 | Release date: | 1998-11-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of an IkappaBalpha/NF-kappaB complex. Cell(Cambridge,Mass.), 95, 1998
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2O61
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7LF4
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3GUT
| Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR | Descriptor: | HIV-LTR Core Forward Strand, HIV-LTR Core Reverse Strand, Nuclear factor NF-kappa-B p105 subunit, ... | Authors: | Stroud, J.C, Oltman, A.J, Han, A, Bates, D.L, Chen, L. | Deposit date: | 2009-03-30 | Release date: | 2009-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.59 Å) | Cite: | Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR. J.Mol.Biol., 393, 2009
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2DBF
| Solution structure of the Death domain in human Nuclear factor NF-kappa-B p105 subunit | Descriptor: | Nuclear factor NF-kappa-B p105 subunit | Authors: | Saito, K, Inoue, M, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-15 | Release date: | 2006-12-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the Death domain in human Nuclear factor NF-kappa-B p105 subunit To be Published
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1MDI
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1MDK
| HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB) | Descriptor: | TARGET SITE IN HUMAN NFKB, THIOREDOXIN | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | Deposit date: | 1995-02-27 | Release date: | 1995-06-03 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure, 3, 1995
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1MDJ
| HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN NFKB (RESIDUES 56-68 OF THE P50 SUBUNIT OF NFKB) | Descriptor: | TARGET SITE IN HUMAN NFKB, THIOREDOXIN | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | Deposit date: | 1995-02-27 | Release date: | 1995-06-03 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure, 3, 1995
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