1ET1
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![BU of 1et1 by Molmil](/molmil-images/mine/1et1) | CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION | Descriptor: | PARATHYROID HORMONE, SODIUM ION | Authors: | Jin, L, Briggs, S.L, Chandrasekhar, S, Chirgadze, N.Y, Clawson, D.K, Schevitz, R.W, Smiley, D.L, Tashjian, A.H, Zhang, F. | Deposit date: | 2000-04-12 | Release date: | 2000-09-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution. J.Biol.Chem., 275, 2000
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3C4M
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8T5F
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![BU of 8t5f by Molmil](/molmil-images/mine/8t5f) | De novo design of high-affinity protein binders to bioactive helical peptides | Descriptor: | Parathyroid hormone | Authors: | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | Deposit date: | 2023-06-13 | Release date: | 2024-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | De novo design of high-affinity binders of bioactive helical peptides. Nature, 626, 2024
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8FLQ
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![BU of 8flq by Molmil](/molmil-images/mine/8flq) | Human PTH1R in complex with PTH(1-34) and Gs | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | Deposit date: | 2022-12-22 | Release date: | 2023-04-26 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
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8HA0
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![BU of 8ha0 by Molmil](/molmil-images/mine/8ha0) | Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, L, Xu, H.E, Yuan, Q. | Deposit date: | 2022-10-26 | Release date: | 2022-12-21 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1. Acta Pharmacol.Sin., 44, 2023
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7Y36
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![BU of 7y36 by Molmil](/molmil-images/mine/7y36) | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | Authors: | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | Deposit date: | 2022-06-10 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex to be published
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7VVL
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![BU of 7vvl by Molmil](/molmil-images/mine/7vvl) | PTH-bound human PTH1R in complex with Gs (class2) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | Deposit date: | 2021-11-06 | Release date: | 2022-08-03 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVM
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![BU of 7vvm by Molmil](/molmil-images/mine/7vvm) | PTH-bound human PTH1R in complex with Gs (class3) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | Deposit date: | 2021-11-06 | Release date: | 2022-08-03 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVK
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![BU of 7vvk by Molmil](/molmil-images/mine/7vvk) | PTH-bound human PTH1R in complex with Gs (class1) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | Deposit date: | 2021-11-06 | Release date: | 2022-08-03 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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8HAO
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![BU of 8hao by Molmil](/molmil-images/mine/8hao) | Human parathyroid hormone receptor-1 dimer | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha, ... | Authors: | Zhao, L, Xu, H.E, Yuan, Q. | Deposit date: | 2022-10-26 | Release date: | 2022-12-21 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1. Acta Pharmacol.Sin., 44, 2023
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7VVN
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![BU of 7vvn by Molmil](/molmil-images/mine/7vvn) | PTH-bound human PTH1R in complex with Gs (class4) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | Deposit date: | 2021-11-06 | Release date: | 2022-08-03 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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7VVO
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![BU of 7vvo by Molmil](/molmil-images/mine/7vvo) | PTH-bound human PTH1R in complex with Gs (class5) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O. | Deposit date: | 2021-11-06 | Release date: | 2022-08-03 | Last modified: | 2023-02-15 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82, 2022
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1BWX
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![BU of 1bwx by Molmil](/molmil-images/mine/1bwx) | THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 1-39, NMR, 10 STRUCTURES | Descriptor: | PARATHYROID HORMONE | Authors: | Marx, U.C, Roesch, P, Adermann, K, Bayer, P, Forssmann, W.-G. | Deposit date: | 1998-09-29 | Release date: | 2000-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000
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1FVY
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1ZWF
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![BU of 1zwf by Molmil](/molmil-images/mine/1zwf) | |
1ZWD
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![BU of 1zwd by Molmil](/molmil-images/mine/1zwd) | |
1HPH
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1ZWA
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![BU of 1zwa by Molmil](/molmil-images/mine/1zwa) | |
1ZWE
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![BU of 1zwe by Molmil](/molmil-images/mine/1zwe) | |
1ZWB
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![BU of 1zwb by Molmil](/molmil-images/mine/1zwb) | |
1ZWG
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1HPY
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![BU of 1hpy by Molmil](/molmil-images/mine/1hpy) | THE SOLUTION STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 1-34 IN 20% TRIFLUORETHANOL, NMR, 10 STRUCTURES | Descriptor: | PARATHYROID HORMONE | Authors: | Marx, U.C, Roesch, P, Adermann, K, Bayer, P, Forssmann, W.-G. | Deposit date: | 1998-09-30 | Release date: | 2000-01-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37). Biochem.Biophys.Res.Commun., 267, 2000
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1HTH
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![BU of 1hth by Molmil](/molmil-images/mine/1hth) | The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures | Descriptor: | CYCLIC PARATHYROID HORMONE | Authors: | Roesch, P, Seidel, G, Schaefer, W, Esswein, A, Hofmann, E. | Deposit date: | 1997-04-09 | Release date: | 1997-10-15 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution. Febs Lett., 444, 1999
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2L1X
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![BU of 2l1x by Molmil](/molmil-images/mine/2l1x) | |