3GKJ
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![BU of 3gkj by Molmil](/molmil-images/mine/3gkj) | NPC1D(NTD):25hydroxycholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25-HYDROXYCHOLESTEROL, ... | Authors: | Kwon, H.J. | Deposit date: | 2009-03-10 | Release date: | 2009-07-14 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell(Cambridge,Mass.), 137, 2009
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3GKI
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![BU of 3gki by Molmil](/molmil-images/mine/3gki) | NPC1(NTD):cholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Kwon, H.J. | Deposit date: | 2009-03-10 | Release date: | 2009-07-14 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell(Cambridge,Mass.), 137, 2009
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3GKH
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![BU of 3gkh by Molmil](/molmil-images/mine/3gkh) | NPC1(NTD) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Kwon, H.J. | Deposit date: | 2009-03-10 | Release date: | 2009-07-14 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell(Cambridge,Mass.), 137, 2009
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5F18
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![BU of 5f18 by Molmil](/molmil-images/mine/5f18) | Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1 | Descriptor: | Niemann-Pick C1 protein | Authors: | Wang, H, Shi, Y, Song, J, Qi, J, Lu, G, Yan, J, Gao, G.F. | Deposit date: | 2015-11-30 | Release date: | 2016-01-20 | Last modified: | 2016-01-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Cell, 164, 2016
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5F1B
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![BU of 5f1b by Molmil](/molmil-images/mine/5f1b) | Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor Niemann-Pick C1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GP1, GP2, ... | Authors: | Wang, H, Shi, Y, Song, J, Qi, J, Lu, G, Yan, J, Gao, G.F. | Deposit date: | 2015-11-30 | Release date: | 2016-01-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. Cell, 164, 2016
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8EUS
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![BU of 8eus by Molmil](/molmil-images/mine/8eus) | Crystal structure of NPC1 luminal domain C | Descriptor: | NPC intracellular cholesterol transporter 1 | Authors: | Odongo, L, Pornillos, O. | Deposit date: | 2022-10-19 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Purification and structure of luminal domain C of human Niemann-Pick C1 protein. Acta Crystallogr.,Sect.F, 79, 2023
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5KWY
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![BU of 5kwy by Molmil](/molmil-images/mine/5kwy) | Structure of human NPC1 middle lumenal domain bound to NPC2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLEST-5-EN-3-YL HYDROGEN SULFATE, Epididymal secretory protein E1, ... | Authors: | Li, X. | Deposit date: | 2016-07-19 | Release date: | 2016-08-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.405 Å) | Cite: | Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HNS
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![BU of 5hns by Molmil](/molmil-images/mine/5hns) | Structure of glycosylated NPC1 luminal domain C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Niemann-Pick C1 protein, ... | Authors: | Zhao, Y, Ren, J, Harlos, K, Stuart, D.I. | Deposit date: | 2016-01-18 | Release date: | 2016-02-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions. Febs Lett., 590, 2016
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6W5S
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![BU of 6w5s by Molmil](/molmil-images/mine/6w5s) | NPC1 structure in GDN micelles at pH 8.0 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, N, Qian, H.W, Wu, X.L. | Deposit date: | 2020-03-13 | Release date: | 2020-06-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182, 2020
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5U74
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![BU of 5u74 by Molmil](/molmil-images/mine/5u74) | Structure of human Niemann-Pick C1 protein | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, X. | Deposit date: | 2016-12-11 | Release date: | 2017-10-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.335 Å) | Cite: | 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U73
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![BU of 5u73 by Molmil](/molmil-images/mine/5u73) | Crystal structure of human Niemann-Pick C1 protein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Niemann-Pick C1 protein, ... | Authors: | Li, X, Wang, J, Blobel, G. | Deposit date: | 2016-12-11 | Release date: | 2017-09-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.348 Å) | Cite: | 3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6W5R
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![BU of 6w5r by Molmil](/molmil-images/mine/6w5r) | NPC1 structure in Nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Yan, N, Qian, H.W, Wu, X.L. | Deposit date: | 2020-03-13 | Release date: | 2020-06-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182, 2020
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6W5T
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![BU of 6w5t by Molmil](/molmil-images/mine/6w5t) | NPC1 structure in GDN micelles at pH 5.5, conformation a | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Yan, N, Qian, H.W, Wu, X.L. | Deposit date: | 2020-03-13 | Release date: | 2020-06-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182, 2020
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6W5U
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![BU of 6w5u by Molmil](/molmil-images/mine/6w5u) | NPC1 structure in GDN micelles at pH 5.5, conformation b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Yan, N, Qian, H.W, Wu, X.L. | Deposit date: | 2020-03-13 | Release date: | 2020-06-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182, 2020
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6W5V
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![BU of 6w5v by Molmil](/molmil-images/mine/6w5v) | NPC1-NPC2 complex structure at pH 5.5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Yan, N, Qian, H.W, Wu, X.L. | Deposit date: | 2020-03-13 | Release date: | 2020-06-17 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell, 182, 2020
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6UOX
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![BU of 6uox by Molmil](/molmil-images/mine/6uox) | Structure of itraconazole-bound NPC1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one, ... | Authors: | Long, T, Li, X. | Deposit date: | 2019-10-15 | Release date: | 2020-01-15 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun, 11, 2020
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3JD8
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![BU of 3jd8 by Molmil](/molmil-images/mine/3jd8) | cryo-EM structure of the full-length human NPC1 at 4.4 angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Zhou, Q, Yan, N. | Deposit date: | 2016-05-01 | Release date: | 2016-06-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | The structure of Niemann-Pick C1 protein To Be Published
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5JNX
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![BU of 5jnx by Molmil](/molmil-images/mine/5jnx) | The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein of Ebola virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ... | Authors: | Gong, X, Qian, H.W, Zhou, X.H, Wu, J.P, Wan, T, Shi, Y, Gao, F, Zhou, Q, Yan, N. | Deposit date: | 2016-05-01 | Release date: | 2016-06-15 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (6.56 Å) | Cite: | Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection Cell, 165, 2016
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