6UOX
Structure of itraconazole-bound NPC1
Summary for 6UOX
Entry DOI | 10.2210/pdb6uox/pdb |
EMDB information | 20834 |
Descriptor | NPC intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | niemann-pick c disease, cholesterol transport, sterol-sensing domain, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 146880.15 |
Authors | |
Primary citation | Long, T.,Qi, X.,Hassan, A.,Liang, Q.,De Brabander, J.K.,Li, X. Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun, 11:152-152, 2020 Cited by PubMed: 31919352DOI: 10.1038/s41467-019-13917-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.13 Å) |
Structure validation
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