6UOX

Structure of itraconazole-bound NPC1

Summary for 6UOX

Entry DOI	10.2210/pdb6uox/pdb
EMDB information	20834
Descriptor	NPC intracellular cholesterol transporter 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	niemann-pick c disease, cholesterol transport, sterol-sensing domain, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	146880.15
Authors	Long, T.,Li, X. (deposition date: 2019-10-15, release date: 2020-01-15, Last modification date: 2020-07-29)
Primary citation	Long, T.,Qi, X.,Hassan, A.,Liang, Q.,De Brabander, J.K.,Li, X. Structural basis for itraconazole-mediated NPC1 inhibition. Nat Commun, 11:152-152, 2020 Cited by PubMed: 31919352 DOI: 10.1038/s41467-019-13917-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.13 Å)

Structure validation