5EHI
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4R8R
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4R8S
| Dengue serotype 3 methyltransferase bound to Sinefungin | Descriptor: | SINEFUNGIN, nonstructural protein NS5 | Authors: | Noble, C.G. | Deposit date: | 2014-09-02 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine Antiviral Res., 111C, 2014
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5EIF
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5EIW
| DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2 | Descriptor: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, NS5 methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Barral, K, Bricogne, G, Sharff, A. | Deposit date: | 2015-10-30 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.611 Å) | Cite: | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
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3P97
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3P8Z
| Dengue Methyltransferase bound to a SAM-based inhibitor | Descriptor: | (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, Non-structural protein 5, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Noble, C.G, Yap, L.J, Lescar, J. | Deposit date: | 2010-10-15 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Small molecule inhibitors that selectively block dengue virus methyltransferase J.Biol.Chem., 286, 2011
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3VTT
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5EC8
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5EKX
| DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11 | Descriptor: | 4-chloro-5-methylbenzene-1,2-diamine, NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE | Authors: | Barral, K, Bricogne, G, Sharff, A. | Deposit date: | 2015-11-04 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
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5E9Q
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5EHG
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3UZE
| Crystal structure of the dengue virus serotype 3 envelope protein domain III in complex with the variable domains of Mab 4E11 | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Envelope protein, ... | Authors: | Cockburn, J.J.B, Navarro Sanchez, M.E, Fretes, N, Urvoas, A, Staropoli, I, Kikuti, C.M, Coffey, L.L, Arenzana Seisdedos, F, Bedouelle, H, Rey, F.A. | Deposit date: | 2011-12-07 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody. Structure, 20, 2012
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4R05
| Crystal structure of the refolded DENV3 methyltransferase | Descriptor: | Nonstructural protein NS5 | Authors: | Brecher, M.B, Li, Z, Zhang, J, Chen, H, Lin, Q, Liu, B, Li, H.M. | Deposit date: | 2014-07-29 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase. Protein Sci., 24, 2015
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7A3T
| Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8 | Descriptor: | Core protein, EDE1 C8 antibody Fab fragment, GLYCEROL, ... | Authors: | Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Rey, F.A. | Deposit date: | 2020-08-18 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
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7A3S
| Crystal structure of dengue 3 virus envelope glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, SULFATE ION | Authors: | Sharma, A, Vaney, M.C, Guardado-Calvo, P, Duquerroy, S, Rouvinski, A, Navarro-Sanchez, E, Rey, F.A. | Deposit date: | 2020-08-18 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses. Cell, 184, 2021
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1UZG
| CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAJOR ENVELOPE PROTEIN E, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Modis, Y, Harrison, S.C. | Deposit date: | 2004-03-11 | Release date: | 2005-03-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein J.Virol., 79, 2005
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5CCV
| Crystal structure of full-length NS5 from dengue virus type 3 | Descriptor: | RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Klema, V.J, Choi, K.H. | Deposit date: | 2015-07-02 | Release date: | 2016-02-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. Plos Pathog., 12, 2016
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