5CCV
Crystal structure of full-length NS5 from dengue virus type 3
Summary for 5CCV
Entry DOI | 10.2210/pdb5ccv/pdb |
Descriptor | RNA-directed RNA polymerase NS5, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total) |
Functional Keywords | methyltransferase, nonstructural protein, transferase |
Biological source | Dengue virus type 3 (DENV-3) |
Cellular location | Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P27915 |
Total number of polymer chains | 8 |
Total formula weight | 837241.70 |
Authors | Klema, V.J.,Choi, K.H. (deposition date: 2015-07-02, release date: 2016-02-03, Last modification date: 2023-09-27) |
Primary citation | Klema, V.J.,Ye, M.,Hindupur, A.,Teramoto, T.,Gottipati, K.,Padmanabhan, R.,Choi, K.H. Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. Plos Pathog., 12:e1005451-e1005451, 2016 Cited by PubMed: 26895240DOI: 10.1371/journal.ppat.1005451 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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