5CCV
Crystal structure of full-length NS5 from dengue virus type 3
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0039694 | biological_process | viral RNA genome replication |
C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
C | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0032259 | biological_process | methylation |
C | 0039694 | biological_process | viral RNA genome replication |
D | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
D | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0032259 | biological_process | methylation |
D | 0039694 | biological_process | viral RNA genome replication |
E | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
E | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
E | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0008168 | molecular_function | methyltransferase activity |
E | 0032259 | biological_process | methylation |
E | 0039694 | biological_process | viral RNA genome replication |
F | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
F | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
F | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0008168 | molecular_function | methyltransferase activity |
F | 0032259 | biological_process | methylation |
F | 0039694 | biological_process | viral RNA genome replication |
G | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
G | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
G | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0008168 | molecular_function | methyltransferase activity |
G | 0032259 | biological_process | methylation |
G | 0039694 | biological_process | viral RNA genome replication |
H | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
H | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
H | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0008168 | molecular_function | methyltransferase activity |
H | 0032259 | biological_process | methylation |
H | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1001 |
Chain | Residue |
A | HIS712 |
A | HIS714 |
A | CYS728 |
A | CYS847 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 1002 |
Chain | Residue |
A | GLU437 |
A | HIS441 |
A | CYS446 |
A | GLY447 |
A | CYS449 |
site_id | AC3 |
Number of Residues | 17 |
Details | binding site for residue SAH A 1003 |
Chain | Residue |
A | SER56 |
A | GLY58 |
A | GLY81 |
A | CYS82 |
A | GLY83 |
A | ARG84 |
A | GLY85 |
A | GLY86 |
A | TRP87 |
A | THR104 |
A | LYS105 |
A | HIS110 |
A | LYS130 |
A | ASP131 |
A | VAL132 |
A | PHE133 |
A | ASP146 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1001 |
Chain | Residue |
B | GLU437 |
B | HIS441 |
B | CYS446 |
B | CYS449 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1002 |
Chain | Residue |
B | HIS712 |
B | HIS714 |
B | CYS728 |
B | CYS847 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue SAH B 1003 |
Chain | Residue |
B | SER56 |
B | GLY58 |
B | GLY81 |
B | CYS82 |
B | GLY83 |
B | GLY86 |
B | TRP87 |
B | LYS105 |
B | HIS110 |
B | GLU111 |
B | LYS130 |
B | ASP131 |
B | VAL132 |
B | PHE133 |
B | ASP146 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN C 1001 |
Chain | Residue |
C | GLU437 |
C | HIS441 |
C | CYS446 |
C | CYS449 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN C 1002 |
Chain | Residue |
C | HIS712 |
C | HIS714 |
C | CYS728 |
C | CYS847 |
site_id | AC9 |
Number of Residues | 15 |
Details | binding site for residue SAH C 1003 |
Chain | Residue |
C | SER56 |
C | GLY58 |
C | GLY81 |
C | CYS82 |
C | GLY83 |
C | GLY86 |
C | TRP87 |
C | THR104 |
C | LYS105 |
C | HIS110 |
C | GLU111 |
C | LYS130 |
C | ASP131 |
C | VAL132 |
C | ASP146 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue ZN D 1001 |
Chain | Residue |
D | GLU437 |
D | HIS441 |
D | CYS446 |
D | GLY447 |
D | CYS449 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN D 1002 |
Chain | Residue |
D | HIS712 |
D | HIS714 |
D | CYS728 |
D | CYS847 |
site_id | AD3 |
Number of Residues | 16 |
Details | binding site for residue SAH D 1003 |
Chain | Residue |
D | SER56 |
D | GLY58 |
D | GLY81 |
D | CYS82 |
D | GLY83 |
D | GLY86 |
D | TRP87 |
D | THR104 |
D | LYS105 |
D | HIS110 |
D | GLU111 |
D | LYS130 |
D | ASP131 |
D | VAL132 |
D | PHE133 |
D | ASP146 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue ZN E 1001 |
Chain | Residue |
E | CYS446 |
E | GLY447 |
E | CYS449 |
E | GLU437 |
E | HIS441 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue ZN E 1002 |
Chain | Residue |
E | HIS712 |
E | HIS714 |
E | CYS728 |
E | CYS847 |
site_id | AD6 |
Number of Residues | 14 |
Details | binding site for residue SAH E 1003 |
Chain | Residue |
E | SER56 |
E | GLY58 |
E | GLY81 |
E | CYS82 |
E | GLY83 |
E | GLY86 |
E | TRP87 |
E | LYS105 |
E | HIS110 |
E | LYS130 |
E | ASP131 |
E | VAL132 |
E | PHE133 |
E | ASP146 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue ZN F 1001 |
Chain | Residue |
F | HIS712 |
F | HIS714 |
F | CYS728 |
F | CYS847 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue ZN F 1002 |
Chain | Residue |
F | GLU437 |
F | HIS441 |
F | CYS446 |
F | CYS449 |
site_id | AD9 |
Number of Residues | 15 |
Details | binding site for residue SAH F 1003 |
Chain | Residue |
F | SER56 |
F | GLY58 |
F | GLY81 |
F | CYS82 |
F | GLY83 |
F | GLY86 |
F | TRP87 |
F | THR104 |
F | LYS105 |
F | HIS110 |
F | LYS130 |
F | ASP131 |
F | VAL132 |
F | PHE133 |
F | ASP146 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue ZN G 1001 |
Chain | Residue |
G | GLU437 |
G | HIS441 |
G | CYS446 |
G | CYS449 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue ZN G 1002 |
Chain | Residue |
G | HIS712 |
G | HIS714 |
G | CYS728 |
G | CYS847 |
site_id | AE3 |
Number of Residues | 18 |
Details | binding site for residue SAH G 1003 |
Chain | Residue |
G | SER56 |
G | GLY58 |
G | GLY81 |
G | CYS82 |
G | GLY83 |
G | GLY85 |
G | GLY86 |
G | TRP87 |
G | THR104 |
G | LYS105 |
G | HIS110 |
G | GLU111 |
G | LYS130 |
G | ASP131 |
G | VAL132 |
G | PHE133 |
G | ASP146 |
G | ILE147 |
site_id | AE4 |
Number of Residues | 4 |
Details | binding site for residue ZN H 1001 |
Chain | Residue |
H | HIS712 |
H | HIS714 |
H | CYS728 |
H | CYS847 |
site_id | AE5 |
Number of Residues | 4 |
Details | binding site for residue ZN H 1002 |
Chain | Residue |
H | GLU437 |
H | HIS441 |
H | CYS446 |
H | CYS449 |
site_id | AE6 |
Number of Residues | 14 |
Details | binding site for residue SAH H 1003 |
Chain | Residue |
H | SER56 |
H | GLY81 |
H | CYS82 |
H | GLY83 |
H | GLY86 |
H | TRP87 |
H | THR104 |
H | LYS105 |
H | HIS110 |
H | GLU111 |
H | LYS130 |
H | ASP131 |
H | VAL132 |
H | ASP146 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 32 |
Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
Chain | Residue | Details |
A | LYS61 | |
A | ASP146 | |
A | LYS180 | |
A | GLU216 | |
B | LYS61 | |
B | ASP146 | |
B | LYS180 | |
B | GLU216 | |
C | LYS61 | |
C | ASP146 | |
C | LYS180 | |
C | GLU216 | |
D | LYS61 | |
D | ASP146 | |
D | LYS180 | |
D | GLU216 | |
E | LYS61 | |
E | ASP146 | |
E | LYS180 | |
E | GLU216 | |
F | LYS61 | |
F | ASP146 | |
F | LYS180 | |
F | GLU216 | |
G | LYS61 | |
G | ASP146 | |
G | LYS180 | |
G | GLU216 | |
H | LYS61 | |
H | ASP146 | |
H | LYS180 | |
H | GLU216 |
site_id | SWS_FT_FI2 |
Number of Residues | 72 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
C | VAL132 | |
C | ILE147 | |
C | TYR218 | |
D | SER56 | |
D | GLY86 | |
D | TRP87 | |
D | THR104 | |
D | LYS105 | |
D | ASP131 | |
D | VAL132 | |
D | ILE147 | |
D | TYR218 | |
E | SER56 | |
E | GLY86 | |
E | TRP87 | |
E | THR104 | |
E | LYS105 | |
E | ASP131 | |
E | VAL132 | |
E | ILE147 | |
E | TYR218 | |
F | SER56 | |
F | GLY86 | |
F | TRP87 | |
F | THR104 | |
F | LYS105 | |
F | ASP131 | |
F | VAL132 | |
F | ILE147 | |
F | TYR218 | |
G | SER56 | |
G | GLY86 | |
G | TRP87 | |
G | THR104 | |
G | LYS105 | |
G | ASP131 | |
G | VAL132 | |
G | ILE147 | |
G | TYR218 | |
H | SER56 | |
H | GLY86 | |
H | TRP87 | |
H | THR104 | |
H | LYS105 | |
H | ASP131 | |
H | VAL132 | |
H | ILE147 | |
H | TYR218 | |
A | SER56 | |
A | GLY86 | |
A | TRP87 | |
A | THR104 | |
A | LYS105 | |
A | ASP131 | |
A | VAL132 | |
A | ILE147 | |
A | TYR218 | |
B | SER56 | |
B | GLY86 | |
B | TRP87 | |
B | THR104 | |
B | LYS105 | |
B | ASP131 | |
B | VAL132 | |
B | ILE147 | |
B | TYR218 | |
C | SER56 | |
C | GLY86 | |
C | TRP87 | |
C | THR104 | |
C | LYS105 | |
C | ASP131 |
site_id | SWS_FT_FI3 |
Number of Residues | 48 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26895240 |
Chain | Residue | Details |
B | CYS446 | |
B | CYS449 | |
B | HIS712 | |
B | CYS728 | |
C | GLU437 | |
C | HIS441 | |
C | CYS446 | |
C | CYS449 | |
C | HIS712 | |
C | CYS728 | |
D | GLU437 | |
D | HIS441 | |
D | CYS446 | |
D | CYS449 | |
D | HIS712 | |
D | CYS728 | |
E | GLU437 | |
E | HIS441 | |
E | CYS446 | |
E | CYS449 | |
E | HIS712 | |
E | CYS728 | |
F | GLU437 | |
F | HIS441 | |
F | CYS446 | |
F | CYS449 | |
F | HIS712 | |
F | CYS728 | |
G | GLU437 | |
G | HIS441 | |
G | CYS446 | |
G | CYS449 | |
G | HIS712 | |
G | CYS728 | |
H | GLU437 | |
H | HIS441 | |
H | CYS446 | |
H | CYS449 | |
H | HIS712 | |
H | CYS728 | |
A | GLU437 | |
A | HIS441 | |
A | CYS446 | |
A | CYS449 | |
A | HIS712 | |
A | CYS728 | |
B | GLU437 | |
B | HIS441 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q6YMS4 |
Chain | Residue | Details |
A | LEU853 | |
B | LEU853 | |
C | LEU853 | |
D | LEU853 | |
E | LEU853 | |
F | LEU853 | |
G | LEU853 | |
H | LEU853 |
site_id | SWS_FT_FI5 |
Number of Residues | 56 |
Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
B | ASN18 | |
B | PHE25 | |
B | LYS29 | |
B | SER150 | |
B | ARG211 | |
B | SER213 | |
C | LYS14 | |
C | ASN18 | |
C | PHE25 | |
C | LYS29 | |
C | SER150 | |
C | ARG211 | |
C | SER213 | |
D | LYS14 | |
D | ASN18 | |
D | PHE25 | |
D | LYS29 | |
D | SER150 | |
D | ARG211 | |
D | SER213 | |
E | LYS14 | |
E | ASN18 | |
E | PHE25 | |
E | LYS29 | |
E | SER150 | |
E | ARG211 | |
E | SER213 | |
F | LYS14 | |
F | ASN18 | |
F | PHE25 | |
F | LYS29 | |
F | SER150 | |
F | ARG211 | |
F | SER213 | |
G | LYS14 | |
G | ASN18 | |
G | PHE25 | |
G | LYS29 | |
G | SER150 | |
G | ARG211 | |
G | SER213 | |
H | LYS14 | |
H | ASN18 | |
H | PHE25 | |
H | LYS29 | |
H | SER150 | |
H | ARG211 | |
H | SER213 | |
A | ASN18 | |
A | PHE25 | |
A | LYS29 | |
A | SER150 | |
A | ARG211 | |
A | SER213 | |
B | LYS14 | |
A | LYS14 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
E | LEU17 | |
E | LEU20 | |
F | LEU17 | |
F | LEU20 | |
G | LEU17 | |
G | LEU20 | |
H | LEU17 | |
H | LEU20 | |
A | LEU17 | |
A | LEU20 | |
B | LEU17 | |
B | LEU20 | |
C | LEU17 | |
C | LEU20 | |
D | LEU17 | |
D | LEU20 |
site_id | SWS_FT_FI7 |
Number of Residues | 24 |
Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS61 | |
A | LYS180 | |
A | GLU216 | |
B | LYS61 | |
B | LYS180 | |
B | GLU216 | |
C | LYS61 | |
C | LYS180 | |
C | GLU216 | |
D | LYS61 | |
D | LYS180 | |
D | GLU216 | |
E | LYS61 | |
E | LYS180 | |
E | GLU216 | |
F | LYS61 | |
F | LYS180 | |
F | GLU216 | |
G | LYS61 | |
G | LYS180 | |
G | GLU216 | |
H | LYS61 | |
H | LYS180 | |
H | GLU216 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | ASP146 | |
B | ASP146 | |
C | ASP146 | |
D | ASP146 | |
E | ASP146 | |
F | ASP146 | |
G | ASP146 | |
H | ASP146 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
Chain | Residue | Details |
A | SER56 | |
B | SER56 | |
C | SER56 | |
D | SER56 | |
E | SER56 | |
F | SER56 | |
G | SER56 | |
H | SER56 |