7XZH
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![BU of 7xzh by Molmil](/molmil-images/mine/7xzh) | Cryo-EM structure of human LRRC8A | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... | Authors: | Liu, H, Liao, J. | Deposit date: | 2022-06-02 | Release date: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | cryo-EM structure of human LRRC8A To Be Published
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8DRK
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![BU of 8drk by Molmil](/molmil-images/mine/8drk) | LRRC8A:C conformation 1 (round) top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DR8
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![BU of 8dr8 by Molmil](/molmil-images/mine/8dr8) | LRRC8A:C conformation 2 (oblong) top mask | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-20 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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7P5V
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![BU of 7p5v by Molmil](/molmil-images/mine/7p5v) | |
8DS3
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![BU of 8ds3 by Molmil](/molmil-images/mine/8ds3) | LRRC8A:C conformation 1 (round) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F74
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![BU of 8f74 by Molmil](/molmil-images/mine/8f74) | LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F77
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![BU of 8f77 by Molmil](/molmil-images/mine/8f77) | LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F79
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![BU of 8f79 by Molmil](/molmil-images/mine/8f79) | LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8F7B
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![BU of 8f7b by Molmil](/molmil-images/mine/8f7b) | LRRC8A(T48D):C conformation 2 top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-11-18 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DS9
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![BU of 8ds9 by Molmil](/molmil-images/mine/8ds9) | LRRC8A:C in MSPE3D1 nanodisc top focus | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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8DRE
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![BU of 8dre by Molmil](/molmil-images/mine/8dre) | LRRC8A:C conformation 2 (oblong) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-20 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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6NZW
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![BU of 6nzw by Molmil](/molmil-images/mine/6nzw) | LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Hite, R.K, Brohawn, S.G. | Deposit date: | 2019-02-14 | Release date: | 2019-02-27 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Elife, 8, 2019
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7P5Y
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![BU of 7p5y by Molmil](/molmil-images/mine/7p5y) | |
6NZZ
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![BU of 6nzz by Molmil](/molmil-images/mine/6nzz) | LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Hite, R.K, Brohawn, S.G. | Deposit date: | 2019-02-14 | Release date: | 2019-02-27 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs. Elife, 8, 2019
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8DXN
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![BU of 8dxn by Molmil](/molmil-images/mine/8dxn) | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 1 | Descriptor: | Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A | Authors: | Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E. | Deposit date: | 2022-08-02 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly. Elife, 12, 2023
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8DSA
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![BU of 8dsa by Molmil](/molmil-images/mine/8dsa) | LRRC8A:C in MSP1E3D1 nanodisc | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C | Authors: | Kern, D.M, Brohawn, S.G. | Deposit date: | 2022-07-21 | Release date: | 2023-03-08 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30, 2023
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7P5W
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![BU of 7p5w by Molmil](/molmil-images/mine/7p5w) | |
8DXO
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![BU of 8dxo by Molmil](/molmil-images/mine/8dxo) | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 2 | Descriptor: | Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A | Authors: | Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E. | Deposit date: | 2022-08-02 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly. Elife, 12, 2023
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7M17
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![BU of 7m17 by Molmil](/molmil-images/mine/7m17) | SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Gerber, E.E, Brohawn, S.G. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022
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6G8Z
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![BU of 6g8z by Molmil](/molmil-images/mine/6g8z) | Structure of the pore domain of homomeric mLRRC8A volume-regulated anion channel at 3.66 A resolution | Descriptor: | Volume-regulated anion channel subunit LRRC8A | Authors: | Sawicka, M, Deneka, D, Lam, A.K.M, Paulino, C, Dutzler, R. | Deposit date: | 2018-04-10 | Release date: | 2018-05-16 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structure of a volume-regulated anion channel of the LRRC8 family. Nature, 558, 2018
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7M19
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![BU of 7m19 by Molmil](/molmil-images/mine/7m19) | SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2) | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A | Authors: | Kern, D.M, Gerber, E.E, Brohawn, S.G. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022
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8DXP
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![BU of 8dxp by Molmil](/molmil-images/mine/8dxp) | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 3 | Descriptor: | Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A | Authors: | Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E. | Deposit date: | 2022-08-02 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly. Elife, 12, 2023
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7P60
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![BU of 7p60 by Molmil](/molmil-images/mine/7p60) | |
7P6K
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![BU of 7p6k by Molmil](/molmil-images/mine/7p6k) | |
8DXQ
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![BU of 8dxq by Molmil](/molmil-images/mine/8dxq) | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 4 | Descriptor: | Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A | Authors: | Takahashi, H, Yamada, T, Denton, J.S, Strange, K, Karakas, E. | Deposit date: | 2022-08-02 | Release date: | 2023-03-22 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly. Elife, 12, 2023
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