7M19

SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)

Summary for 7M19

• Entry DOI: 10.2210/pdb7m19/pdb
• Related: 7M17
• EMDB information: 23614 23616
• Descriptor: Volume-regulated anion channel subunit LRRC8A, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid (3 entities in total)
• Functional Keywords: ion channel, inhibitor, membrane protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 6
• Total formula weight: 585407.10

Authors

Kern, D.M.,Gerber, E.E.,Brohawn, S.G. (deposition date: 2021-03-12, release date: 2021-03-24, Last modification date: 2022-02-23)

• Primary citation: Gunasekar, S.K.,Xie, L.,Kumar, A.,Hong, J.,Chheda, P.R.,Kang, C.,Kern, D.M.,My-Ta, C.,Maurer, J.,Heebink, J.,Gerber, E.E.,Grzesik, W.J.,Elliot-Hudson, M.,Zhang, Y.,Key, P.,Kulkarni, C.A.,Beals, J.W.,Smith, G.I.,Samuel, I.,Smith, J.K.,Nau, P.,Imai, Y.,Sheldon, R.D.,Taylor, E.B.,Lerner, D.J.,Norris, A.W.,Klein, S.,Brohawn, S.G.,Kerns, R.,Sah, R.; Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.; Nat Commun, 13:784-784, 2022; PubMed: 35145074; DOI: 10.1038/s41467-022-28435-0

Experimental method

ELECTRON MICROSCOPY (3.69 Å)