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7URG
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BU of 7urg by Molmil
cryo-EM structure of ribonucleotide reductase from Synechococcus phage S-CBP4 bound with TTP
Descriptor: Ribonucleotide reductase, THYMIDINE-5'-TRIPHOSPHATE
Authors:Xu, D, Burnim, A.A, Ando, N.
Deposit date:2022-04-21
Release date:2022-09-07
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade.
Elife, 11, 2022
6DQX
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BU of 6dqx by Molmil
Actinobacillus ureae class Id ribonucleotide reductase alpha subunit
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:McBride, M.J, Palowitch, G.M, Boal, A.K.
Deposit date:2018-06-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.
Biochemistry, 58, 2019
6DQW
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BU of 6dqw by Molmil
Flavobacterium johnsoniae class Id ribonucleotide reductase alpha subuint
Descriptor: Ribonucleoside-diphosphate reductase, alpha chain
Authors:Maggiolo, A.O, Boal, A.K.
Deposit date:2018-06-11
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.
Biochemistry, 58, 2019
7B9Q
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BU of 7b9q by Molmil
The SERp optimized structure of Ribonucleotide reductase from Rhodobacter sphaeroides
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase
Authors:Loderer, C, Feiler, C, Wilk, P, Kabinger, F.
Deposit date:2020-12-14
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase.
Biochemistry, 61, 2022
7B9P
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BU of 7b9p by Molmil
Structure of Ribonucleotide reductase from Rhodobacter sphaeroides
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Vitamin B12-dependent ribonucleotide reductase
Authors:Wilk, P, Feiler, C, Loderer, C, Kabinger, F.
Deposit date:2020-12-14
Release date:2022-01-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase.
Biochemistry, 61, 2022
6R1R
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BU of 6r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441D MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
7R1R
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BU of 7r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441Q MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
5D1Y
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BU of 5d1y by Molmil
Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP
Descriptor: Ribonucleoside-diphosphate reductase large subunit
Authors:Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L.
Deposit date:2015-08-04
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (9.005 Å)
Cite:Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.
Biochemistry, 55, 2016
7RW6
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BU of 7rw6 by Molmil
BORF2-APOBEC3Bctd Complex
Descriptor: DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION
Authors:Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S.
Deposit date:2021-08-19
Release date:2022-04-27
Last modified:2022-05-04
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
6L3R
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BU of 6l3r by Molmil
Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide
Descriptor: 4-bromo-N-((1S,2R)-2-(naphthalen-1-yl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)benzenesulfonamide, ACETATE ION, MAGNESIUM ION, ...
Authors:Miyahara, S, Chong, K.T, Suzuki, T.
Deposit date:2019-10-15
Release date:2020-10-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
4X3V
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BU of 4x3v by Molmil
Crystal structure of human ribonucleotide reductase 1 bound to inhibitor
Descriptor: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE
Authors:Dealwis, C.G, Ahmad, M.F, Alam, I.
Deposit date:2014-12-01
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.
J.Med.Chem., 58, 2015
7AGJ
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BU of 7agj by Molmil
Ribonucleotide Reductase R1 protein from Aquifex aeolicus
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Rehling, D, Scaletti, E.R, Stenmark, P.
Deposit date:2020-09-22
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry, 61, 2022
5IM3
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BU of 5im3 by Molmil
Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase
Authors:Johansson, R, Logan, D.T.
Deposit date:2016-03-05
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones.
Structure, 24, 2016
4R1R
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BU of 4r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH SUBSTRATE, GDP AND EFFECTOR DTTP FROM ESCHERICHIA COLI
Descriptor: GUANOSINE-5'-DIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN, ...
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-07-22
Release date:1998-01-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
7MDI
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BU of 7mdi by Molmil
Structure of the Neisseria gonorrhoeae ribonucleotide reductase in the inactive state
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Levitz, T.S, Drennan, C.L, Brignole, E.J.
Deposit date:2021-04-05
Release date:2022-01-05
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.
J.Struct.Biol., 214, 2021
6W4X
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BU of 6w4x by Molmil
Holocomplex of E. coli class Ia ribonucleotide reductase with GDP and TTP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ...
Authors:Kang, G, Taguchi, A, Stubbe, J, Drennan, C.
Deposit date:2020-03-11
Release date:2020-04-08
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.
Science, 368, 2020
3UUS
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BU of 3uus by Molmil
Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, FE (III) ION, Ribonucleoside-diphosphate reductase 1 subunit alpha, ...
Authors:Zimanyi, C.M, Drennan, C.L.
Deposit date:2011-11-28
Release date:2011-12-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (5.65 Å)
Cite:Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.
Proc.Natl.Acad.Sci.USA, 108, 2011
2XO5
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BU of 2xo5 by Molmil
RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI
Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J.
Deposit date:2010-08-09
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases.
J.Am.Chem.Soc., 133, 2011
5R1R
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BU of 5r1r by Molmil
RIBONUCLEOTIDE REDUCTASE E441A MUTANT R1 PROTEIN FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-09-17
Release date:1998-03-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductase.
J.Biol.Chem., 272, 1997
2XO4
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BU of 2xo4 by Molmil
RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI
Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA
Authors:Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J.
Deposit date:2010-08-09
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases.
J.Am.Chem.Soc., 133, 2011
2ZLF
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BU of 2zlf by Molmil
The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase
Descriptor: FTLDADF, Ribonucleoside-diphosphate reductase large chain 1
Authors:Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
1R1R
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BU of 1r1r by Molmil
RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI
Descriptor: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN
Authors:Eriksson, M, Eklund, H.
Deposit date:1997-07-15
Release date:1998-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.
Structure, 5, 1997
5TUS
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BU of 5tus by Molmil
Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule
Descriptor: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ...
Authors:Mohammed, F.A, Alam, I, Dealwis, C.G.
Deposit date:2016-11-07
Release date:2017-08-02
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1RLR
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BU of 1rlr by Molmil
STRUCTURE OF RIBONUCLEOTIDE REDUCTASE PROTEIN R1
Descriptor: RIBONUCLEOTIDE REDUCTASE PROTEIN R1
Authors:Uhlin, U, Eklund, H.
Deposit date:1994-08-12
Release date:1996-12-23
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of ribonucleotide reductase protein R1.
Nature, 370, 1994
2ZLG
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BU of 2zlg by Molmil
The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase
Descriptor: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1
Authors:Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008

 

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數據於2024-07-10公開中

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