1TRZ
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1TYM
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3ZQR
| NMePheB25 insulin analogue crystal structure | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Antolikova, E, Zakova, L, Turkenburg, J.P, Watson, C.J, Hanclova, I, Sanda, M, Cooper, A, Kraus, T, Brzozowski, A.M, Jiracek, J.A. | Deposit date: | 2011-06-10 | Release date: | 2011-08-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface. J.Biol.Chem., 286, 2011
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3ZU1
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4CXL
| Human insulin analogue (D-ProB8)-insulin | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | Deposit date: | 2014-04-07 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
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4CXN
| Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | Deposit date: | 2014-04-07 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
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5BTS
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1SF1
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2WS1
| Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-03 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2VJZ
| Crystal structure form ultalente insulin microcrystals | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Wagner, A, Diez, J, Schulze-Briese, C, Schluckebier, G. | Deposit date: | 2007-12-14 | Release date: | 2008-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Ultralente-A Microcrystalline Insulin Suspension. Proteins, 74, 2009
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2WS6
| Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form | Descriptor: | CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-03 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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1TGR
| Crystal Structure of mini-IGF-1(2) | Descriptor: | Insulin-like growth factor IA | Authors: | Liang, D.C, Yun, C.H, Chang, W.R. | Deposit date: | 2004-05-29 | Release date: | 2004-12-28 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | 1.42A crystal structure of mini-IGF-1(2): an analysis of the disulfide isomerization property and receptor binding property of IGF-1 based on the three-dimensional structure Biochem.Biophys.Res.Commun., 326, 2004
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4CY7
| Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. | Deposit date: | 2014-04-10 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
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2WS0
| Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-03 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRX
| Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-02 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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5E7W
| X-ray Structure of Human Recombinant 2Zn insulin at 0.92 Angstrom | Descriptor: | ACETATE ION, Insulin, N-PROPANOL, ... | Authors: | Lisgarten, D.R, Naylor, C.E, Palmer, R.A, Lobley, C.M.C. | Deposit date: | 2015-10-13 | Release date: | 2016-10-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (0.9519 Å) | Cite: | Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K. Chem Cent J, 11, 2017
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1UZ9
| Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins. | Descriptor: | (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, CHLORIDE ION, INSULIN, ... | Authors: | Whittingham, J.L, Jonassen, I, Havelund, S, Roberts, S.M, Dodson, E.J, Verma, C.S, Wilkinson, A.J, Dodson, G.G. | Deposit date: | 2004-03-08 | Release date: | 2005-03-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins Biochemistry, 43, 2004
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1SJU
| MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES | Descriptor: | PROINSULIN | Authors: | Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 1997-10-09 | Release date: | 1998-03-18 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures. J.Mol.Biol., 277, 1998
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1T1P
| NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | Descriptor: | Insulin, insulin | Authors: | Huang, K, Xu, B, Hu, S.Q, Chu, Y.C, Hua, Q.X, Whittaker, J, Nakagawa, S.H, De Meyts, P, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2004-04-16 | Release date: | 2004-08-10 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor. J.Mol.Biol., 341, 2004
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5T7R
| A6-A11 trans-dicarba human insulin | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. | Deposit date: | 2016-09-05 | Release date: | 2017-12-06 | Last modified: | 2019-06-19 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
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1EV6
| Structure of the monoclinic form of the M-cresol/insulin R6 hexamer | Descriptor: | CHLORIDE ION, INSULIN, M-CRESOL, ... | Authors: | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | Deposit date: | 2000-04-19 | Release date: | 2000-12-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol Biochem.Biophys.Res.Commun., 56, 2000
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1EVR
| The structure of the resorcinol/insulin R6 hexamer | Descriptor: | CHLORIDE ION, INSULIN, RESORCINOL, ... | Authors: | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | Deposit date: | 2000-04-20 | Release date: | 2000-12-04 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | R6 hexameric insulin complexed with m-cresol or resorcinol. Acta Crystallogr.,Sect.D, 56, 2000
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1EFE
| AN ACTIVE MINI-PROINSULIN, M2PI | Descriptor: | MINI-PROINSULIN | Authors: | Cho, Y, Chang, S.G, Choi, K.D, Shin, H, Ahn, B, Kim, K.S. | Deposit date: | 2000-02-08 | Release date: | 2000-03-17 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Solution Structure of an Active Mini-Proinsulin, M2PI: Inter-chain Flexibility is Crucial for Insulin Activity J.Biochem.Mol.Biol., 33, 2000
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5USP
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5URT
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