6X8M
| CryoEM structure of the holo-SrpI encapsulin complex from Synechococcus elongatus PCC 7942 | Descriptor: | Protein SrpI | Authors: | LaFrance, B.J, Nichols, R.J, Phillips, N.R, Oltrogge, L.M, Valentin-Alvarado, L.E, Bischoff, A.J, Savage, D.F, Nogales, E. | Deposit date: | 2020-06-01 | Release date: | 2020-06-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism. Elife, 10, 2021
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6X8T
| CryoEM structure of the apo-SrpI encapasulin complex from Synechococcus elongatus PCC 7942 | Descriptor: | Protein SrpI | Authors: | LaFrance, B.J, Nichols, R.J, Phillips, N.R, Oltrogge, L.M, Valentin-Alvarado, L.E, Bischoff, A.J, Savage, D.F, Nogales, E. | Deposit date: | 2020-06-01 | Release date: | 2020-06-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism. Elife, 10, 2021
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8A3Q
| Human Plasma Kallekrein in complex with 14W | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein, ... | Authors: | McEwan, P.A. | Deposit date: | 2022-06-08 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. J.Med.Chem., 65, 2022
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6EUA
| The fibrinogen-like domain of human Angptl3 | Descriptor: | Angiopoietin-related protein 3 | Authors: | Biterova, E.I, Esmaeeli, M.E, Alanen, H.I, Saaranen, M, Ruddock, L.W. | Deposit date: | 2017-10-30 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease. Sci Rep, 8, 2018
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6EUB
| The fibrinogen-like domain of human Angptl4 | Descriptor: | Angiopoietin-related protein 4, PENTAETHYLENE GLYCOL | Authors: | Biterova, E.I, Esmaeeli, M, Alanen, H.I, Saaranen, M, Ruddock, L.W. | Deposit date: | 2017-10-30 | Release date: | 2018-05-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease. Sci Rep, 8, 2018
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7F27
| Crystal structure of polyketide ketosynthase | Descriptor: | 3-oxoacyl-(Acyl-carrier-protein) synthase | Authors: | Kim, Y, Lee, W.C. | Deposit date: | 2021-06-10 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis. Sci Rep, 11, 2021
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7F28
| Crystal structure of a bacterial ketosynthase | Descriptor: | Ketoacyl_synth_N domain-containing protein, Putative 3-oxoacyl-[ACP] synthase FabV | Authors: | Lee, W.C, Kim, Y. | Deposit date: | 2021-06-10 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.877 Å) | Cite: | Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis. Sci Rep, 11, 2021
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1R7I
| HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution. | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION | Authors: | Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V. | Deposit date: | 2003-10-21 | Release date: | 2003-11-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase. To be Published
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7BC0
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7BC1
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5ZEC
| Crystal structure of Kluyveromyces polyspora ADH (KpADH) mutant (Q136N/F161V/S196G/E214G/S237C) | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ETHANOL, ... | Authors: | Wang, Y, ZHou, J.Y, Hou, X.D, Xu, G.C, Rao, Y.J, Wu, L, Zhou, J.H, Ni, Y. | Deposit date: | 2018-02-27 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.779 Å) | Cite: | Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones. J. Am. Chem. Soc., 140, 2018
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5Z2X
| Structure of Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) | Descriptor: | 1,2-ETHANEDIOL, Alcohol dehydrogenase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, Y, Zhou, J.Y, Hou, X.D, Xu, G.C, Wu, L, Rao, Y.J, ZHou, J.H, Ni, Y. | Deposit date: | 2018-01-04 | Release date: | 2019-01-02 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones. J. Am. Chem. Soc., 140, 2018
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8OVI
| BRICHOS monomer | Descriptor: | Pulmonary surfactant-associated protein C (Fragment) | Authors: | Ghosh, D, Torres, F, Guentert, P, Riek, R. | Deposit date: | 2023-04-26 | Release date: | 2024-06-26 | Method: | SOLUTION NMR | Cite: | The inhibitory action of the chaperone BRICHOS against the alpha-Synuclein secondary nucleation pathway at near-atomic resolution To Be Published
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8OX2
| BRICHOS trimer | Descriptor: | Pulmonary surfactant-associated protein C | Authors: | Ghosh, D, Torres, F, Guentert, P, Riek, R. | Deposit date: | 2023-04-30 | Release date: | 2024-06-26 | Method: | SOLUTION NMR | Cite: | The inhibitory action of the chaperone BRICHOS against the alpha-Synuclein secondary nucleation pathway at near-atomic resolution To Be Published
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3HEA
| The L29P/L124I mutation of Pseudomonas fluorescens esterase | Descriptor: | Arylesterase, ETHYL ACETATE, GLYCEROL, ... | Authors: | Kazlauskas, R.J, Schrag, J.D, Cheeseman, J.D, Morley, K.L. | Deposit date: | 2009-05-08 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase. Biochemistry, 49, 2010
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5JCW
| Crystal Structure of hGSTP1-1 with Glutathione Adduct of Phenethyl Isothiocyanate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Kumari, V, Ji, X. | Deposit date: | 2016-04-15 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. Plos One, 11, 2016
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3Q6T
| Salivary protein from Lutzomyia longipalpis, Ligand free | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-03 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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3Q6P
| Salivary protein from Lutzomyia longipalpis. Selenomethionine derivative | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-03 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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3L0E
| X-ray crystal structure of a Potent Liver X Receptor Modulator | Descriptor: | N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide, Nuclear receptor coactivator 2, Oxysterols receptor LXR-beta | Authors: | Gampe Jr, R.T. | Deposit date: | 2009-12-09 | Release date: | 2010-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J.Med.Chem., 53, 2010
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3Q6K
| Salivary protein from Lutzomyia longipalpis | Descriptor: | 43.2 kDa salivary protein, CITRIC ACID, SEROTONIN | Authors: | Andersen, J.F, Xu, X, Chang, B.W, Collin, N, Valenzuela, J.G, Ribeiro, J.M. | Deposit date: | 2011-01-02 | Release date: | 2011-07-27 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. J.Biol.Chem., 286, 2011
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7JPH
| Crystal structure of EBOV glycoprotein with modified HR1c and HR2 stalk at 3.2 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ... | Authors: | Chaudhary, A, Stanfield, R.L, Wilson, I.A, Zhu, J. | Deposit date: | 2020-08-08 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.195 Å) | Cite: | Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines. Nat Commun, 12, 2021
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5U9A
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5U9J
| Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with geranyl geranyl pyrophoshate | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), GERAN-8-YL GERAN, ISOPROPYL ALCOHOL, ... | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2016-12-16 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U9I
| Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2016-12-16 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V35
| Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester | Descriptor: | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1), FARNESYL | Authors: | Yadav, R.P, Gakhar, L, Liping, Y, Artemyev, N.O. | Deposit date: | 2017-03-06 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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